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Human Immunodeficiency Virus-Associated Lymphoproliferative Disorders

机译:人类免疫缺陷病毒相关的淋巴抑制性疾病

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摘要

HIV infection is associated with an increased risk for developing B-cell lymphoproliferative disorders. The spectrum of disease differs in HIV-infected versus HIV-uninfected persons, with aggressive B-cell non-Hodgkin lym-phomas constituting a higher proportion of all lymphoproliferative disorders in the HIV-positive population. Although antiretroviral therapy (ART) has significantly changed the landscape of lym-phomas arising in HIV-infected persons, population growth and aging are reflected in the steady increase in non-AIDS-defining cancers. In the ART era, outcomes for HIV-infected lymphoma patients are similar to those of HIV-negative patients. This article reviews the diagnostic features and summarizes current biologic understanding of HlV-associated lymphomas.
机译:HIV感染与发育B细胞淋巴抑制性疾病的风险增加有关。 疾病的差异在艾滋病毒感染与艾滋病毒 - 未感染的人中不同,具有侵略性的B细胞非霍奇金淋巴结,其构成艾滋病毒阳性群体中所有淋巴抑制性疾病的比例较高。 虽然抗逆转录病毒治疗(ART)显着改变了艾滋病毒感染者所产生的Lym-Phomas的景观,但群体的生长和衰老反映在无艾滋病定义癌症的稳定增加中。 在本文中,HIV感染淋巴瘤患者的结果与HIV阴性患者的结果类似。 本文审查了诊断特征,总结了对HLV相关淋巴瘤的目前的生物学理解。

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