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Prognostic and Predictive Biomarkers in Diffuse Large B-cell Lymphoma

机译:弥漫性大B细胞淋巴瘤的预后和预测生物标志物

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摘要

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy in the Western world, accounting for 25% to 40% of adult non-Hodgkin lymphomas (NHLs), with at least 25,000 new cases in the United States estimated in 2016. The disease is remarkably heterogeneous, with a variety of pathogenetic mechanisms, presentations, and outcomes. Since the introduction of cyclophosphamide, doxorubicin, vincris-tine, and prednisone plus rituximab (R-CHOP) as the standard therapy for DLBCL, approximately 60% of patients are now curable. For those who are not cured, the disease is often progressive and fatal.1 Because of DLBCL's heterogeneity, extensive research has been performed with an aim to stratify patients based on prognosis, identify patients who would be cured by R-CHOP, and identify others who would benefit from novel therapies. This article synthesizes this research.
机译:弥漫性大B细胞淋巴瘤(DLBCL)是西方世界上最常见的淋巴恶性肿瘤,占成年非霍奇金淋巴瘤(NHLS)的25%至40%,在2016年估计美国至少有25,000例新案件 。该疾病具有显着的异质性,具有各种致病机制,介绍和结果。 由于引入环磷酰胺,多柔比蛋白,Vincris-Tine和Prednisone Plus rituximab(R-Chec)作为DLBCL的标准治疗,现在可以治愈约60%的患者。 对于那些没有治愈的人,由于DLBCL的异质性,这种疾病往往是渐进的,致命的致命情况,已经进行了广泛的研究,目的是在基于预后分析患者,鉴定由R-Chec治愈的患者,并识别他人 谁将受益于新的疗法。 本文综合了这项研究。

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