Update on Peripheral Nerve Sheath Tumors

Anthony P. Martinez; Karen J. Fritchie

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Update on Peripheral Nerve Sheath Tumors

机译：更新周围神经鞘瘤

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Recent work has revealed SMARCB1/INI1 loss by immunohistochemistry in a subset of epithelioid schwannomas and explored the significance of cytologic atypia and increased mitotic activity in these tumors. Additional studies have evaluated the utility and limitations of histone H3K27 trimethylation in diagnosis of high-grade and low-grade malignant peripheral nerve sheath tumors. New terminology regarding nerve sheath tumors in neurofibromatosis type 1 patients was proposed during a 2016 conference to better define guidelines for classification of this group of tumors. This review highlights novel findings and practical applications relating to these topics in peripheral nerve sheath tumors.

机译：最近的工作已经揭示了免疫组织化学在上皮细胞施韦马斯的子集中的SMARCB1 / INI1损失，并探讨了这些肿瘤中细胞学原型和增加的有丝分裂活性的重要性。额外的研究已经评估了组蛋白H3K27三甲基化的实用性和限制在诊断高级和低级恶性周围神经鞘蜂窝中的诊断中。在2016年会议期间提出了关于神经纤维瘤病患者神经鞘瘤的新术语，以更好地确定该组肿瘤分类指南。本综述突出了与周围神经鞘瘤中的这些主题有关的新调查结果和实际应用。

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来源
《Surgical pathology clinics》 |2019年第1期|共19页
作者
Anthony P. Martinez; Karen J. Fritchie;
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作者单位

Department of Laboratory Medicine and Pathology Mayo Clinic 200 First Street Southwest Rochester;

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原文格式 PDF
正文语种 eng
中图分类病理学;
关键词
SMARCB1/INI1 H3K27me3 Epithelioid schwannoma Nerve sheath tumors;

机译：SMARCB1 / INI1 H3K27ME3上皮细胞施瓦新瘤神经鞘瘤;

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专利

1. Inaccurate summary of peripheral nerve sheath tumors in extradigital sites.Comment on "Hybrid peripheral nerve sheath tumor of the nasal cavityshowing schwannomatous, neurofibromatus, and perineuriomatous areas.Med Mol Morphol (2010) 43:82-85" [J] . Teresa Pusiol, Maria Grazia Zorzi, Doriana Morichetti, Medical Molecular Morphology . 2010,第4期

机译：指外部位周围神经鞘瘤的摘要不准确。评论“鼻腔混合神经鞘瘤显示神经鞘瘤，神经纤维瘤和神经周围瘤区域。MedMol Morphol（2010）43：82-85”
2. Updates on the diagnosis and treatment of intracranial nerve malignant peripheral nerve sheath tumors [J] . Bénédicte LHeureux-Lebeau, Issam Saliba OncoTargets and therapy . 2013,第2期

机译：颅内神经恶性周围神经鞘瘤的诊治进展
3. HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor [J] . Pei Hui, Ning Li, Chaline Johnson, Modern Pathology . 2005,第11期

机译：HMGA蛋白在恶性周围神经鞘瘤和滑膜肉瘤中的表达：HMGA2在恶性周围神经鞘瘤中的优先表达
4. RESPONSE OF NERVE SHEATH TUMORS AFFECTING THE SPINAL CORD TO TREATMENT: 8 CASES [C] . Bonnie L Brugmann, Bridget K Urie, Andy Shores, Annual conference of the Veterinary Cancer Society . 2008

机译：神经鞘瘤影响脊髓治疗的响应：8例
5. RABL6A Signaling as an Oncogenic Driver and Therapeutic Target in Malignant Peripheral Nerve Sheath Tumors (MPNST) [D] . Kohlmeyer, Jordan L. 2021

机译：Rabl6a以恶性外周神经鞘肿瘤（MPNST）为致癌驾驶员和治疗靶标
6. Updates on the diagnosis and treatment of intracranial nerve malignant peripheral nerve sheath tumors [O] . Bénédicte L’Heureux-Lebeau, Issam Saliba 2013

机译：颅内神经恶性周围神经鞘瘤的诊治进展
7. Overexpression of cyclooxygenase-2 in malignant peripheral nerve sheath tumor and selective cyclooxygenase-2 inhibitor-induced apoptosis by activating caspases in human malignant peripheral nerve sheath tumor cells. [O] . Michiyuki Hakozaki, Takahiro Tajino, Shinichi Konno, 2014

机译：环恶氧化酶-2在恶性外周神经鞘膜瘤中的过表达及选择性环氧合酶-2抑制剂诱导人恶性外周神经鞘膜瘤中caspase的凋亡。

Update on Peripheral Nerve Sheath Tumors

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