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Molecular Genetics of Pancreatic Neoplasms

机译:胰腺肿瘤的分子遗传学

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摘要

Pancreatic neoplasms have a wide range of histologic types with distinct clinical outcomes. Recent advances in high-throughput sequencing technologies have greatly deepened our understanding of pancreatic neoplasms. Now, the exomes of major histologic types of pancreatic neoplasms have been sequenced, and their genetic landscapes have been revealed. This article reviews the molecular changes underlying pancreatic neoplasms, with a special focus on the genetic changes that characterize the histologic types of pancreatic neoplasms. Emphasis is also made on the molecular features of key genes that have the potential for therapeutic targets.
机译:胰腺肿瘤具有各种组织学类型,具有不同的临床结果。 高通量测序技术的最新进展极大地深化了我们对胰腺的理解。 现在,已经测量了主要组织学类型的主要组织学类型的胰腺类型的外部,并且已经揭示了它们的遗传景观。 本文综述了胰腺肿瘤下面的分子变化,特别关注胰腺组织学类型的遗传变化。 强调还对具有治疗目标可能潜力的关键基因的分子特征。

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