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首页> 外文期刊>PACE: Pacing and clinical electrophysiology >Single oral administration of pilsicainide versus infusion of disopyramide for termination of paroxysmal atrial fibrillation: a multicenter trial.
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Single oral administration of pilsicainide versus infusion of disopyramide for termination of paroxysmal atrial fibrillation: a multicenter trial.

机译：综合口服施用碱性施用与致释放术终止术终止剂：多中心试验。

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A single oral dose of pilsicainide (PLS) is effective in terminating acute-onset atrial fibrillation (AF). However, the effectiveness of this single oral treatment has not been compared with the infusion of other antiarrhythmic drugs. The effects of a single oral dose of PLS on the termination of AF were compared with an infusion of disopyramide (DISO) in a multicenter trial. Seventy-two patients with electrocardiographically confirmed, symptomatic, paroxysmal AF (< 48-hour duration) were randomized to receive either a single 100- to 150-mg dose of PLS versus a 2 mg/kg (maximum dose = 100 mg) infusion of DISO. Successful defibrillation was defined as termination of AF within 2 hours of drug administration. Conversion of AF to sinus rhythm was achieved within 2 hours in 29 of 40 patients (73%) treated with PLS, and in 18 of 32 patients (56%) treated with DISO (NS). The mean time to return of sinus rhythm was 60 +/- 30 minutes in the PLS group versus 23 +/- 18 minutes in the DISO group (P < 0.001). DISO was particularly effective in terminating nocturnal AF, whereas PLS had a stable circadian effect. PLS was significantly more effective than DISO between 6 AM and 12 PM (64% vs 17%, P < 0.05). No adverse effect was observed in either group. In conclusion, a single oral dose of PLS was as effective as an infusion of DISO to restore sinus rhythm in patients with recent-onset AF. PLS consistently terminated AF regardless of its time of onset.
机译：单个口服剂量的碱性碱（PLS）是有效终止急性发作的心房颤动（AF）。然而，与其他抗心律失常药物的输注进行了比较了这种单一口服处理的有效性。将单个口服剂量PLS对AF终止的影响与多中心试验中的二甲酰（Diso）进行比较。七十二名心电图证实的患者，症状阵发性AF（<48小时持续时间）被随机化以接收单个100至150mg剂量的PLS与2mg / kg（最大剂量= 100mg）输注祛湿。成功的除颤被定义为药物给药后2小时内的AF终止。用PLS处理的40名患者（73％）中的29例中，在29例（73％）中，在32例患者（56％）中达到29例，患有鼻窦节律，并用Diso（ns）处理。在PLS组中，窦性节律的平均时间为60 +/- 30分钟，在DISO组中为23 +/- 18分钟（P <0.001）。 Diso在终止夜间AF方面特别有效，而PLS具有稳定的昼夜疗效。 PLS比早上6点至下午12点至下午12点的祛湿更有效（64％Vs 17％，P <0.05）。在任一组中没有观察到不良影响。总之，单个口服剂量的PLS作为输注衰竭以恢复急诊患者的鼻窦节律。无论其发病时间如何，请始终终止AF。

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