• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Sleep >Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A(2A) Receptors in Sleep-Pain Interactions
【24h】

Preemptive Caffeine Administration Blocks the Increase in Postoperative Pain Caused by Previous Sleep Loss in the Rat: A Potential Role for Preoptic Adenosine A(2A) Receptors in Sleep-Pain Interactions

机译：先发制人的咖啡因给药阻断了大鼠睡眠损失引起的术后疼痛的增加：睡眠疼痛相互作用中临床腺苷A（2A）受体的潜在作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sleep and pain are reciprocally related, but the precise mechanisms underlying this relationship are poorly understood. This study used a rat model of surgical pain to examine the effect of previous sleep loss on postoperative pain and tested the hypothesis that preoptic adenosinergic mechanisms regulate sleep-pain interactions. Relative to ad libitum sleep, 6 hours of total sleep deprivation prior to a surgical incision significantly enhanced postoperative mechanical hypersensitivity in the affected paw and prolonged the time to recovery from surgery. There were no sex-specific differences in these measures. There were also no changes in adrenocorticotropic hormone and corticosterone levels after sleep deprivation, suggesting that this effect was not mediated by the stress associated with the sleep perturbation. Systemic administration of the nonselective adenosine receptor antagonist caffeine at the onset of sleep deprivation prevented the sleep deprivation-induced increase in postoperative hypersensitivity. Microinjection of the adenosine A(2A) receptor antagonist ZM 241385 into the median preoptic nucleus (MnPO) blocked the increase in surgical pain levels and duration caused by prior sleep deprivation and eliminated the thermal hyperalgesia induced by sleep deprivation in a group of nonoperated (i.e., without surgical incision) rats. These data show that even a brief sleep disturbance prior to surgery worsens postoperative pain and are consistent with our hypothesis that adenosine A(2A) receptors in the MnPO contribute to regulate these sleep-pain interactions.
机译：睡眠和疼痛是相互相关的，但这种关系的基本机制很差。这项研究用来了对术后疼痛的先前睡眠损失的大鼠模型，并测试了临床腺嘌呤能机制调节睡眠疼痛相互作用的假设。相对于自由睡眠，在手术切口之前6小时的总睡眠剥夺，显着增强了受影响的爪子的术后机械超敏反应，并延长了从手术中恢复的时间。这些措施没有性别特异性差异。睡眠剥夺后的肾上腺皮质激素和皮质酮水平也没有变化，表明这种效果未被与睡眠扰动相关的应激介导。在睡眠剥夺发作时，NONEERECTIVE腺苷受体拮抗剂咖啡因的全身施用阻止了睡眠剥夺诱导的术后超敏反应增加。腺苷A（2A）受体拮抗剂ZM 241385进入中值核（MNPO）的微注射阻断了由先前睡眠剥夺引起的手术疼痛水平和持续时间的增加，并消除了一组非睡眠（即，没有手术切口）大鼠。这些数据表明，即使在手术前发短的睡眠障碍也恶化术后疼痛，并且与我们的假设一致，即MNPO中的腺苷A（2A）受体有助于调节这些睡眠疼痛相互作用。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号