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A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis

机译：失眠症中缺乏一致的脑改变：激活似然估计Meta分析

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Insomnia disorder is a prevalent sleep disorder, which affects about 10% of general population. However, its neural mechanisms are poorly understood. Recently, several structural and functional neuroimaging studies have been conducted in patients with insomnia disorder, but these studies have yielded diverse findings. Here, we aimed to identify consistent patterns of abnormal brain alterations in insomnia disorder by performing a quantitative coordinate-based meta-analysis. Following the preferred reporting for systematic reviews and meta-analyses statement, we searched PubMed database and used reference tracking and finally retrieved 19 eligible studies (six task-based functional magnetic resonance imaging, eight resting-state functional magnetic resonance imaging, three voxel-based morphometry, and two positron emission tomography). We extracted peak coordinates from these studies and tested for convergence using the activation likelihood estimation method. Using this method, we found no significant convergent evidence for combination of structural atrophy and functional disturbances across previous studies (p = 0.914). Inconsistencies across these studies might be related to heterogonous clinical populations, the explorative nature of these studies in combination with small sample sizes, different experimental designs, and various preprocessing and statistical approaches. Future neuroimaging studies on insomnia disorder should include larger well-characterized samples, as well as standard imaging and analysis protocols. (c) 2018 Elsevier Ltd. All rights reserved.
机译：失眠症是一种普遍的睡眠障碍，其占总人口的10％。然而，它的神经机制理解得很差。最近，已经在失眠症的患者中进行了几项结构和功能性神经影像学研究，但这些研究产生了不同的发现。在这里，我们旨在通过进行定量坐标的荟萃分析来鉴定失眠症紊乱的异常脑改变的一致模式。遵循系统评测和Meta-Analys的首选报告，我们搜索了PubMed数据库并使用了参考跟踪，最后检索了19个合格的研究（六项任务基功能磁共振成像，八个休息状态功能磁共振成像，三个基于体素形态学和两个正电子发射断层扫描）。我们从这些研究中提取了峰坐标并使用激活似然估计方法进行收敛。使用这种方法，我们发现没有显着的会聚证据，用于在先前研究中的结构萎缩和功能性干扰组合（p = 0.914）。这些研究中的不一致可能与异质临床群体有关，这些研究的探索性与小样本尺寸，不同的实验设计和各种预处理和统计方法的组合。对失眠症的未来神经影像学研究应包括较大的特征样品，以及标准成像和分析方案。 （c）2018年elestvier有限公司保留所有权利。

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