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首页> 外文期刊>Pain medicine : >Reduction of Opioid Use by Acupuncture in Patients Undergoing Hematopoietic Stem Cell Transplantation: Secondary Analysis of a Randomized, Sham-Controlled Trial
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Reduction of Opioid Use by Acupuncture in Patients Undergoing Hematopoietic Stem Cell Transplantation: Secondary Analysis of a Randomized, Sham-Controlled Trial

机译：针灸在经过造血干细胞移植患者中使用针灸的用途：随机，假对照试验的二次分析

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摘要

Objective. To evaluate acupuncture as a nonpharmacologic intervention for pain management in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods. Adult patients with multiple myeloma undergoing high-dose melphalan chemotherapy and autologous peripheral blood HSCT were randomized to receive either true (TA) or sham acupuncture (SA) once daily for five days starting on the day after chemotherapy. Use of pain medications and pain scores were assessed at baseline and at days 5, 15, and 30 after transplantation. Results. Among 60 evaluable subjects, the SA group (vs TA) had greater than five times odds of increasing pain medication use from baseline. Among patients who were opioid nonusers at baseline, all 15 patients in the TA group remained free from opioid use at the end of the study. In contrast, 20% of those in the SA group (four of the 20 patients) started to use opioids after chemotherapy and stem cell infusion (day 5) and 40% (eight of the 20) had become opioid users by day 30 after HSCT (Fisher exact test P= 0.006). Among patients who were taking opioids at baseline, 14% in the TA group vs 10% in the SA group increased opioid intake at day 5, and 21% (TA) vs 30% (SA) at day 30 (P= 0.86). Conclusions. Acupuncture appears to significantly reduce the need for pain medications during HSCT and the number of post-HSCT opioid users among baseline opioid nonusers. It warrants further studies as an opioid-sparing intervention for pain in HSCT patients.
机译：客观的。评估针灸作为造血干细胞移植患者疼痛管理的非武装干预措施（HSCT）。方法。成年患有多种骨髓瘤的患者进行高剂量蛋白酶化疗和自体外周血HSCT随机，每天一次每天一次接受真正的（TA）或假穴（SA），从而在化疗后一天开始。在移植后，在基线和第5,15天和第5天和30天使用止痛药和疼痛评分。结果。在60个可评估的受试者中，SA组（VS TA）增加了从基线增加止痛药的疼痛药物的可能性大于五倍。在基线的阿片类药物的患者中，TA中的所有15名患者在研究结束时仍然没有阿片类药物。相比之下，在化疗和干细胞输注（第5天）后，SA组（20名患者中有四名患者中的四个）的20％开始使用阿片类药物在HSCT之后第30天成为阿片类药物的40％（20日）。 （Fisher精确测试P = 0.006）。在基线服用阿片类药物的患者中，在SA组的TA组与10％在第5天增加阿片类摄入量，第30天（P = 0.86）增加21％（TA）与30％（SA）。结论。针灸似乎显着降低了HSCT期间对疼痛药物的需求以及基线阿片类药物非用户的HSCT阿片类药物的数量。它需要进一步研究作为HSCT患者疼痛的阿片类药物备注干预。

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  • 来源
    《Pain medicine :》 |2020年第3期|共7页
  • 作者

    Deng Gary; Giralt Sergio; Chung David J.; Landau Heather; Siman Jonathan; Li Qing S.; Lapen Kaitlyn; Mao Jun J.;

  • 作者单位

    Mem Sloan Kettering Canc Ctr Integrat Med Serv New York NY 10021 USA;

    Mem Sloan Kettering Canc Ctr Adult Bone Marrow Transplantat Serv New York NY 10021 USA;

    Mem Sloan Kettering Canc Ctr Adult Bone Marrow Transplantat Serv New York NY 10021 USA;

    Mem Sloan Kettering Canc Ctr Adult Bone Marrow Transplantat Serv New York NY 10021 USA;

    Seattle Canc Care Alliance Seattle WA USA;

    Mem Sloan Kettering Canc Ctr Integrat Med Serv New York NY 10021 USA;

    Univ Illinois Sch Med Chicago IL USA;

    Mem Sloan Kettering Canc Ctr Integrat Med Serv New York NY 10021 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 症状诊断学;
  • 关键词

    Pain Management; Acupuncture; Opioids; Cancer Pain;

    机译：疼痛管理;针灸;阿片类药物;癌症疼痛;

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