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首页> 外文期刊>Pain medicine : >Short-term Efficiency and Tolerance of Ketoprofen and Methylprednisolone in Acute Sciatica: A Randomized Trial
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Short-term Efficiency and Tolerance of Ketoprofen and Methylprednisolone in Acute Sciatica: A Randomized Trial

机译：急性坐骨神经痛中酮丙烯和甲基己酮酮的短期效率和耐受性：随机试验

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Objective. Although anti-inflammatory drugs are commonly used in acute discogenic sciatica, data regarding their efficacy are scarce and controversial. We compared the efficacy and safety of intravenous ketoprofen and methylprednisolone with placebo in sciatica. Design. Multicenter, double-blinded randomized controlled trial. Subjects. Patients with confirmed discogenic acute sciatica, without neurologic deficit, were randomized into three arms. Methods. Besides standard-of-care analgesic therapy, they received intravenous injections of methylprednisolone (60 mg/d) or ketoprofen (200 mg/d) or placebo for five days. The primary outcome was leg pain over five days. Secondary outcomes were clinical responses at days 3 and 5, lumbar pain, Straight Leg Raise Test and lumbar flexion index, analgesic consumption, realization of lumbar spine injections, and surgery during the study period. Results. Fifty-four patients were randomized, and 50 completed the study. In patients admitted to the hospital for pain control with acute lumbar radicular pain due to intervertebral disc herniation and receiving an oral analgesic protocol including paracetamol, nefopam, tramadol, and morphine, there was no additional analgesic effect seen between groups. There was no significant difference in leg pain between the three groups over the study period. In the methylprednisolone group, however, we observed a higher rate of clinically relevant responses at day 3. No difference was observed on other secondary efficacy outcomes and safety. Conclusion. No significant difference in leg pain was observed between groups. However, there was a higher proportion of patients relieved with intravenous methylprednisolone at day 3, compared with ketoprofen or placebo.
机译：客观的。虽然抗炎药通常用于急性椎间盘坐骨神经痛，但有关其疗效的数据是稀缺和争议的。将静脉内酮庚烯和甲基己二甲酮与安慰剂中的静脉内酮和甲基己酮醇的疗效和安全进行了比较。设计。多中心，双盲随机对照试验。主题。患有确认的致病急性坐骨神经痛，没有神经缺陷，被随机分为三个臂。方法。除护理标准镇痛治疗外，它们还接受静脉注射甲基丙酮醇（60mg / d）或酮丁香（200mg / d）或安慰剂5天。主要结果是腿部疼痛五天。二次结果是第3天和第5天和第5天的临床反应，腰痛，直腿提高试验和腰部屈曲指数，镇痛消费，腰椎注射的实现，以及在研究期间的手术。结果。五十四名患者随机化，50名完成研究。在患有椎间盘突出症的急性腰部疼痛的患者患有急性腰部疼痛的患者中，接受口腔镇痛方案，包括扑热息痛，奈福泮，曲马多和吗啡，在组之间没有额外的镇痛作用。在研究期间三组之间的腿部疼痛没有显着差异。然而，在甲基己酮组中，我们在第3天观察到较高的临床相关响应率。在其他二次疗效结果和安全性没有观察到差异。结论。在组之间观察到腿部疼痛的显着差异。然而，与酮丙烯或安慰剂相比，在第3天与静脉内甲基己二溶酮减轻了更高比例的患者。

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