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首页> 外文期刊>Pain medicine : >Opioid-Induced Reductions in Gait Variability in Healthy Volunteers and Individuals with Knee Osteoarthritis
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Opioid-Induced Reductions in Gait Variability in Healthy Volunteers and Individuals with Knee Osteoarthritis

机译：阿片类药物诱导在健康志愿者和膝关节骨关节炎的个体中的步态变异的减少

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摘要

Objective. To investigate differences in gait variability induced by two different single-dose opioid formulations and an inert placebo in healthy volunteers and knee osteoarthritis patients. Design. Experimental, randomized, double-blinded, crossover study of inert placebo (calcium tablets), 50 mg of tapentadol, and 100 mg of tramadol. Setting. Laboratory setting. Subjects. Healthy volunteers and knee osteoarthritis patients. Methods. At three visits, separated by seven days, one tablet was administered per visit according to the randomization code. At each visit, a baseline measurement was done before tablet administration, after which hourly measurements were performed for six hours, yielding a total of seven measurements per visit. Gait variability was measured by three-dimensional gait analysis, recorded during six minutes of continuous treadmill walking at self-selected speed. One hundred seventy gait cycles were identified from detection of clear events of the knee joint angle trajectories. Gait variability was assessed as average standard deviations over a gait cycle of the sacrum displacements and accelerations; sagittal plane ankle, knee, and hip joint angles; step widths; and stride times. Results. Twenty-four opioid-naive and neurologically intact participants (12 healthy volunteers and 12 knee osteoarthritis patients) were included and completed the experiment. Tapentadol reduced the variability of sacrum displacements and accelerations compared with placebo and tramadol. There were no differences between experimental conditions regarding the variability in lower-extremity joint angle variability, step widths, or stride times. Conclusions. In opioid-naive and neurologically intact individuals, tapentadol seems to reduce movement variability during treadmill walking, compared with placebo and tramadol. This can be interpreted as a loss of adaptability that might increase the risk of falling if the system is perturbed.
机译：客观的。为了研究两种不同单剂量阿片类药物配方和健康志愿者和膝关节骨关节炎患者的两种不同单剂量阿片类药物和惰性安慰剂诱导的步态变异性的差异。设计。惰性安慰剂（钙片），50mg Tabentadol和100mg曲马多的实验，随机，双盲，交叉研究。环境。实验室环境。主题。健康的志愿者和膝关节骨关节炎患者。方法。在三次访问中，分隔七天，根据随机化代码每次访问一片平板电脑。在每次访问时，在片剂给药前进行基线测量，之后进行每小时测量六小时，每次访问总共七次测量。通过三维步态分析测量步态可变性，记录在六分钟的连续跑步机以自选速度行走。从检测到膝关节角轨迹的清晰事件检测到一百七十个步态周期。在骶骨流离失所和加速度的步态周期上评估了步态变异性作为平均标准偏差;矢状平面脚踝，膝盖和髋关节角;步宽;和步幅。结果。包括二十四个阿片类药物和神经学完整的参与者（12名健康志愿者和12名膝关节育耳炎患者）并完成了实验。 Tapentadol与安慰剂和曲马多相比，降低了骶骨位移和加速度的可变性。关于下肢关节角度变异性，步进宽度或步幅时的可变性之间的实验条件之间没有差异。结论。在阿片类幼稚和神经根学完整的个体中，与安慰剂和曲马多相比，Tapentadol似乎减少了跑步机行走过程中的运动变异性。如果系统扰乱，这可以解释为可能会增加落下风险的适应性。

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  • 来源
    《Pain medicine :》 |2019年第11期|共9页
  • 作者

    Henriksen Marius; Alkjaer Tine; Raffalt Peter C.; Jorgensen Louse; Bartholdy Cecilie; Hansen Steen Honore; Bliddal Henning;

  • 作者单位

    Copenhagen Univ Hosp Bispebjerg Frederiksberg Parker Inst Ndr Fasanvej 57 DK-2000 Copenhagen F;

    Copenhagen Univ Hosp Bispebjerg Frederiksberg Dept Phys &

    Occupat Therapy Copenhagen Denmark;

    Univ Copenhagen Dept Biomed Sci Copenhagen Denmark;

    Univ Copenhagen Dept Biomed Sci Copenhagen Denmark;

    Copenhagen Univ Hosp Bispebjerg Frederiksberg Parker Inst Ndr Fasanvej 57 DK-2000 Copenhagen F;

    Univ Copenhagen Fac Hlth &

    Med Sci Dept Pharm Analyt Biosci Copenhagen Denmark;

    Copenhagen Univ Hosp Bispebjerg Frederiksberg Parker Inst Ndr Fasanvej 57 DK-2000 Copenhagen F;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 症状诊断学;
  • 关键词

    Gait Analysis; Gait Variability; Opioids;

    机译：步态分析;步态变异;阿片类药物;

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