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Zinc-clotrimazole complexes are effective against Trichomonas vaginalis

机译：锌 - 克拉咪唑络合物对滴虫的阴道有效

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摘要

Trichomonas vaginalis is a protozoan parasite that causes trichomoniasis in humans, the most prevalent non-viral sexually transmitted disease (STD). Imidazole compounds are used for the treatment of trichomoniasis, and metronidazole is the most commonly prescribed. However, these compounds can lead to parasite resistance and unwanted side effects. Therefore, there is a need for an alternative treatment for this disease. Here, we explored the potential of clotrimazole (CTZ) and zinc compounds, as well as CTZ complexed with zinc salts ([1] acetate [Zn(CTZ)2(Ac)2] and [2] a chloride [Zn(CTZ)2Cl2] complexes) against T. vaginalis. We synthesized the zinc complexed CTZ compounds and determined their concentration values that inhibited parasite growth by 50% (IC50). We used scanning and transmission electron microscopy to visualize the ultrastructural alterations induced by CTZ and their zinc complexes. The incubation of the parasites with [Zn(CTZ)2(Ac)2] complex inhibited their growth, yielding an IC50 of 4.9 μm. Moreover, there were changes in the shape of treated parasites, including the formation of surface projections that subsequently detached from the cell, in addition to changes in the hydrogenosomes, endoplasmic reticulum and Golgi complex. We found [Zn(CTZ)2(Ac)2] to be a highly effective compound against T. vaginalis in vitro, suggesting its potential utility as an alternative chemotherapy for trichomoniasis.
机译：Trichomonas阴道是一种原生动物寄生虫，导致人类的滴虫病，最普遍的非病毒性传播疾病（STD）。咪唑化合物用于治疗滴虫病，甲硝唑是最常见的。然而，这些化合物可导致寄生虫抗性和不需要的副作用。因此，需要替代治疗这种疾病。在此，我们探讨了克拉咪唑（CTZ）和锌化合物的潜力，以及用锌盐（[1]乙酸盐[Zn（CTZ）2（AC）2]和[2]氯化物络合的CTZ络合物[Zn（CTZ） 2cl2]复合物）针对阴道。我们合成锌络合物的CTZ化合物，并确定其浓度值，抑制寄生虫生长50％（IC 50）。我们使用扫描和透射电子显微镜可视化CTZ及其锌络合物诱导的超微结构改变。寄生虫与[Zn（CTZ）2（AC）2]复合物孵育它们的生长，得到4.9μm的IC50。此外，除了脱氢剂，内质网和高尔基复合物的变化之外，还存在处理寄生虫的形状的变化，包括形成随后从细胞中脱离的表面突起。我们发现[Zn（CTZ）2（AC）2]是对体外的高效阴道的高效化合物，表明其作为Trichomoniaisis的替代化疗的潜在效用。

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