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Overview of the role of kinetoplastid surface carbohydrates in infection and host cell invasion: prospects for therapeutic intervention

机译：KINETOPLASTID表面碳水化合物在感染和宿主细胞入侵中的作用概述：治疗干预前景

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摘要

Kinetoplastid parasites are responsible for serious diseases in humans and livestock such as Chagas disease and sleeping sickness (caused by Trypanosoma cruzi and Trypanosoma brucei, respectively), and the different forms of cutaneous, mucocutaneous and visceral leishmaniasis (produced by Leishmania spp). The limited number of antiparasitic drugs available together with the emergence of resistance underscores the need for new therapeutic agents with novel mechanisms of action. The use of agents binding to surface glycans has been recently suggested as a new approach to antitrypanosomal design and a series of peptidic and non-peptidic carbohydrate-binding agents have been identified as antiparasitics showing efficacy in animal models of sleeping sickness. Here we provide an overview of the nature of surface glycans in three kinetoplastid parasites, T. cruzi, T. brucei and Leishmania. Their role in virulence and host cell invasion is highlighted with the aim of identifying specific glycan–lectin interactions and carbohydrate functions that may be the target of novel carbohydrate-binding agents with therapeutic applications.
机译：Kinetoplastid寄生虫是人类和牲畜的严重疾病，如赤字疾病和睡眠疾病（分别由锥瘤瘤瘤和锥虫瘤Brucei引起的），以及不同形式的皮肤，粘膜皮肤和内脏Leishmaniaisis（由Leishmania SPP产生）。有限数量的抗脂质药物可用于抵抗的出现，强调了具有新的治疗剂，具有新的作用机制的新治疗剂。最近已经建议使用与表面聚糖结合的药剂作为抗核糖体设计的新方法，并且已经鉴定了一系列肽和非肽碳水化合物结合剂的抗脂质和非肽碳水化合物结合剂，以显示睡眠疾病的动物模型中的疗效。在这里，我们概述了三个Kinetoplastid寄生虫中表面聚糖的性质，T.Cruzi，T.Brucei和Leishmania。它们在毒力和宿主细胞侵袭中的作用是突出的，目的是鉴定特定的聚糖凝集素相互作用和碳水化合物功能，这可能是具有治疗应用的新型碳水化合物结合剂的靶标。

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