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首页> 外文期刊>Parasitology >Fatal Theileria orientalis N2 genotype infection among Asian water buffaloes (Bubalus bubalis) in a commercial dairy farm in Kerala, India
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Fatal Theileria orientalis N2 genotype infection among Asian water buffaloes (Bubalus bubalis) in a commercial dairy farm in Kerala, India

机译：亚洲水牛中致命的Theileria Orientalis N2基因型感染在印度喀拉拉邦的商业乳制品农场中

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Fifteen dairy buffaloes of a farm in the state of Kerala, India developed fatal oriental theileriosis within 2 months of their procurement. Typical piroplasms of Theileria orientalis were observed in the erythrocytes of all affected animals by Giemsa-Leishman staining of blood smears. Case fatality rate was 87.5% (seven out of eight) in the clinically progressed cases. Therapeutic management with anti-theilerial drugs buparvaquone and oxytetracycline led to recovery of seven other animals in less advanced stages of the disease. The aim of this study was to determine the reasons for increased virulence of this pathogen, hitherto considered to be benign. Acute haemolytic anaemia was the predominant haematological finding in the affected animals. Lymphocytic infiltration and degeneration of vital organs leading to functional derangement was the cause of the high mortality. Identification of T. orientalis was confirmed by polymerase chain reaction (PCR). DNA sequencing of the PCR products revealed close identity with already reported sequences of T. orientalis/buffeli N2 genotype. The sequences were deposited in GenBank with accession number KM609973 and KM043772. Rhipicephalus ticks, previously not reported as vectors for oriental theileriosis, were identified as the potential vectors. This is the first report of fatal oriental theileriosis in Asian water buffaloes.
机译：印度喀拉拉邦州的一场农场的十五个乳制品水牛，在他们采购的2个月内发育了致命的东方特性。通过Giemsa-Leishman染色的血液涂片，在所有受影响动物的红细胞中观察到Theileria Orientalis的典型原粒。临床进展情况下，病例死亡率为87.5％（八分之七）。具有抗疏入性药物的治疗性管理Buparvaquone和催眠素导致患有七种疾病的晚期阶段的七种其他动物。本研究的目的是确定该病原体毒力增加的原因，迄今为止被认为是良性的。急性溶血性贫血是受影响的动物中的主要血液学发现。淋巴细胞浸润和导致功能性紊乱的重要器官退化是高死亡率的原因。通过聚合酶链反应（PCR）证实了T. Orientalis的鉴定。 PCR产物的DNA测序揭示了已经报道的T. Orientalis / Buffeli N2基因型的序列的密切同一性。序列被沉积在Genbank中，登录号KM609973和KM043772。以前未报告的Rapicephalus蜱虫被识别为潜在的载体。这是亚洲水牛致命东方致命事故的第一份报告。

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