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首页> 外文期刊>Parasitology >Why calpain inhibitors are interesting leading compounds to search for new therapeutic options to treat leishmaniasis?
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Why calpain inhibitors are interesting leading compounds to search for new therapeutic options to treat leishmaniasis?

机译：为什么Calpain抑制剂是有趣的领先化合物，用于寻找新的治疗利什曼病？

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Leishmaniasis is a neglected disease, which needs improvements in drug development, mainly due to the toxicity, parasite resistance and low compliance of patients to treatment. Therefore, the development of new chemotherapeutic compounds is an urgent need. This opinion article will briefly highlight the feasible use of calpain inhibitors as leading compounds to search for new therapeutic options to treat leishmaniasis. The milestone of this approach is to take advantage on the myriad of inhibitors developed against calpains, some of which are in advanced clinical trials. The deregulated activity of these enzymes is associated with several pathologies, such as strokes, diabetes and Parkinson's disease, to name a few. In Leishmania, calpain upregulation has been associated to drug resistance and virulence. Whereas the difficulties in developing new drugs for neglected diseases are more economical than biotechnological, repurposing approach with compounds already approved for clinical use by the regulatory agencies can be an interesting shortcut to a successful chemotherapeutic treatment for leishmaniasis.
机译：Leishmaniaisis是一种被忽视的疾病，需要改善药物发育，主要是由于毒性，寄生虫抗性和患者治疗的低依从性。因此，新化学治疗化合物的发展是迫切需要的。本文将简要介绍鲤鱼抑制剂作为前导化合物的可行性使用，以寻找治疗利什曼病的新治疗选择。这种方法的里程碑是利用对Calpains开发的无数抑制剂，其中一些是在晚期临床试验中。这些酶的潜眠活性与几种病理学相关，例如中风，糖尿病和帕金森病，以命名几个。在利什曼尼亚，卡尔佩恩上调与耐药性和毒力有关。鉴于为忽视疾病开发新药物的困难比生物技术更经济，而且已经批准了监管机构临床用途的复发方法可能是对LeishManiaisis成功化学治疗的有趣捷径。

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