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首页> 外文期刊>Parasitology >Cross-reactivity of the 31 kDa antigen of Angiostrongylus cantonensis - Dealing with the immunodiagnosis of meningoencephalitis
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Cross-reactivity of the 31 kDa antigen of Angiostrongylus cantonensis - Dealing with the immunodiagnosis of meningoencephalitis

机译：Angiostrongylus Cantonensis的31 kda抗原的交叉反应性 - 处理脑膜炎的免疫诊断

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摘要

The primary causative agent of eosinophilic meningoencephalitis (EoM) in endemic regions is the nematode Angiostrongylus cantonensis. The occurrence of EoM was previously restricted to countries in Southeast Asia and the Pacific Islands; however, more recently, it has been reported from other regions, including Brazil. The commonly used diagnosis is detection of specific antibody reactivity to the 31 kDa antigen, which is derived from female worm somatic extracts. Here we report the occurrence of cross-reactivity to this antigen in sera from other parasitic infections, especially those that may cause EoM, such as gnathostomiasis, toxocariasis, hydatidosis and strongyloidiasis. We also demonstrated that the cross-reactivity, in part, is dependent of the concentration of antigen used in Western blot assays. We discuss the importance of these findings on the interpretation of this test.
机译：流行区域中嗜酸性脑膜炎血细胞炎（EOM）的主要致病剂是Nematode Angiostrongylus Cantonensis。 EOM的发生以前仅限于东南亚和太平洋岛屿的国家; 然而，最近，它已经从包括巴西在内的其他地区报道。 常用的诊断是检测到31kDa抗原的特异性抗体反应性，其衍生自雌性蠕虫体细胞提取物。 在这里，我们向来自其他寄生虫感染的血清中这种抗原的交叉反应性发生的发生，特别是那些可能导致核心病原体，毒素，毒性病变和抗酮化病变。 我们还证明了交叉反应性，部分地取决于蛋白质印迹测定中使用的抗原的浓度。 我们讨论了这些调查结果对对该测试的解释的重要性。

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