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首页> 外文期刊>Parasitology >The relationship of endotoxaemia to peripheral and central nervous system inflammatory responses in Human African Trypanosomiasis
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The relationship of endotoxaemia to peripheral and central nervous system inflammatory responses in Human African Trypanosomiasis

机译：内卵肿血与外周和中枢神经系统炎症反应的关系

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摘要

Endotoxaemia has been described in cases of Human African trypanosomiasis (HAT), but it is unclear if this phenomenon influences inflammatory pathology either in the periphery or central nervous system (CNS). We studied endotoxin concentrations in the plasma and cerebrospinal fluid (CSF) of Trypanosoma brucei rhodesiense patients using the chromogenic Limulus Amoebocyte lysate assay. The relationship of endotoxin concentration to the presentation of gross signs of inflammation and the inflammatory/counter-inflammatory cytokine profile of the relevant compartments were analysed. We demonstrate that HAT patients exhibit parasitaemia-independent plasma endotoxaemia, and that this is associated with splenomegaly and lymphadenopathy. Endotoxin concentrations normalize rapidly after treatment. There was no evidence of endotoxin release in the CNS. A rapid normalization of endotoxin levels after treatment and lack of association with parasitaemia suggest that gut leakage is the main source of endotoxin in the circulation. Low CSF endotoxin concentrations and a lack of any association with neuroinflammatory markers or neurological sequelae suggest that endotoxin does not play a role in the pathogenesis of the disease in the CNS.
机译：在人类非洲锥虫病（帽子）的情况下已经描述了内卵肿大，但目前尚不清楚这种现象是影响炎症病理学在外围或中枢神经系统（CNS）中。我们使用发色束amoebocyte裂解物测定法研究了锥虫瘤的血浆和脑脊液（CSF）中的内毒素浓度。分析了内毒素浓度与相关隔间的炎症粗迹表呈递的关系，以及相关隔间的炎症/反炎细胞因子剖面。我们证明帽子患者表现出寄生虫独立的血浆内卵肿瘤，这与脾肿大和淋巴结病相关。内毒素浓度在处理后迅速归一化。 CNS中没有证据表明内毒素释放。治疗后内毒素水平的快速正常化，缺乏与寄生虫缺乏关联表明肠道泄漏是循环中内毒素的主要来源。低CSF内毒素浓度和缺乏与神经胰腺炎标记物或神经外因的关联表明内毒素在CNS中疾病的发病机制中没有发挥作用。

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