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首页> 外文期刊>Parasitology >Host-specific serological response to Angiostrongylus vasorum infection in red foxes (Vulpes vulpes): implications for parasite epidemiology
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Host-specific serological response to Angiostrongylus vasorum infection in red foxes (Vulpes vulpes): implications for parasite epidemiology

机译：宿主特异性血清学反应红狐狸（狐狸狐狸）中的Angiostrongylus vasorum感染：对寄生虫流行病学的影响

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摘要

Angiostrongylus vasorum is a cardiovascular nematode increasingly found in dogs and foxes in endemic foci throughout Europe. The present study evaluates ELISAs for detection of circulating antigens and specific antibodies against A. vasorum in foxes. Blood and worm burdens (WBs) from carcasses of 215 Swiss wild red foxes (Vulpes vulpes) and from 75 farmed foxes of different age groups experimentally inoculated once or repeatedly with infective doses of 50, 100 or 200 third-stage larvae were obtained. Antigen detection in the naturally infected Swiss foxes had 91.2% sensitivity and 89.4% specificity, whereas the corresponding figures for antibody detection were 42.2 and 92.0%. The experimentally infected foxes became positive for circulating antigens 5-10 weeks post-inoculation (wpi) and remained highly positive up to 22 wpi, irrespectively of further challenge inoculation. The antibody responses in the same foxes were highly variable: high optical density (OD) values were reached 5-7 wpi in all animals, followed by a decrease in over half of the animals despite accumulating and consequently high WBs resulting in persistent infections. After each challenge, a slight increase of OD values was observed 7 weeks later. We hypothesize that infected foxes develop a variable and non-protective immunity. Such parasite tolerance allows long-term survival of A. vasorum in the animals, and may explain why the parasite appears to spread rapidly within a fox population, an epidemiological dynamic that is evident in many parts of Europe where A. vasorum has been found over the last decades.
机译：Angiostrongylus vasorum是一种心血管线虫，越来越多地发现在欧洲的特有焦点的狗和狐狸。本研究评估了ELISA检测狐狸血管血管血管血管抗原和特异性抗体。从215瑞士野生红狐狸（狐狸狐狸）和75个不同年龄组的养殖狐狸的血液和蠕虫）和不同年龄群的75个养殖狐狸得到一次或用50,100或200三阶段幼虫的感染剂量进行一次或反复接种。天然感染的瑞士狐狸中的抗原检测具有91.2％的灵敏度和89.4％的特异性，而抗体检测的相应图为42.2和92.0％。实验感染的狐狸对接种后5-10周循环抗原的阳性（WPI），不断地对接种的进一步挑战，其保持高达22 WPI的高度阳性。同一狐烷中的抗体反应是高度变化的：在所有动物中达到5-7个WPI的高光密度（OD）值，然后仍然存在累积并导致持续的感染的高WBS在一半的动物中减少。在每次挑战后，7周后观察到OD值的略微增加。我们假设感染的狐狸发育变量和非保护免疫力。这种寄生虫耐受性允许在动物中长期存活A.血管血管毒素，并且可以解释为什么寄生虫似乎在狐狸群体中迅速扩散，这是一个在欧洲许多地方明显的流行病学动态，其中A. Vasorum已经发现最后几十年。

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