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首页> 外文期刊>Parasitology >The &ITin vitro&IT anthelmintic activity of the ethanol leaf extracts of &ITTerminalia catappa&IT L. on &ITFasciola gigantica&IT
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The &ITin vitro&IT anthelmintic activity of the ethanol leaf extracts of &ITTerminalia catappa&IT L. on &ITFasciola gigantica&IT

机译：＆Itin体外＆IT＆IT＆Itterminalia Catappa＆IT L. On＆Itfasciola Gigantica及其

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摘要

At present, there are no medicinal plant extracts currently available for treatment and control of fasciolosis. The present work could provide, for the first study, conclusions on the in vitro fasciolicidal properties of the ethanol extract of Terminalia catappa L. (TcCE) leaves against adult Fasciola gigantica after incubation with RPM1-1 640 medium containing the TcCE at various concentrations and times when compared with triclabendazole (TCZ). The relative motility and survival index values of the TcGE-treated flukes decreased at a more rapid rate than the TCZ-treated flukes. The death of the parasites was observed after exposed to TcCE at 3 h incubation with 400, 800 and 1000/mu g mL(-1), and at 6 h incubation in 100 and 200 mu g mL(-1). Vacuolization, blebbings and partial disruption on the parasites' tegument were observed by light-microscopy. When examined by scanning electron microscopy, TcCE caused similar tegumental alterations in the parasites as those observed in TCZ treatment but with larger damage at comparative incubation periods, consisting of swelling, blobbing, disrupted blebs, loss of spines, leading to the erosion, lesion and eventual disruption of the total tegument. Therefore, the TcCE may-exert its fasciolicidal effect against F. gigantica by initially causing the tegumental alteration.
机译：目前，目前没有药用植物提取物用于治疗和控制扇状化。对于第一次研究，本作者可以提供关于紫杉醇提取物的乙醇提取物的乙醇提取物（TCCE）的体外迷离特性与在各种浓度下含有TCCE的RPM1-1640培养基中的成人诉讼吉生物的乙醇提取物。与三胞唑（TCZ）相比时的时间。 TCGE治疗的氟克斯的相对运动和存活指数值以比TCZ治疗的氟尿更快的速率降低。在用400,800和1000 / mu Gml（-1）温育下将TCCE暴露于TCCE后观察到寄生虫的死亡，并在100和200μg（-1）中孵育6小时。通过光显微镜观察寄生虫的真空化，膨胀和部分破坏。当通过扫描电子显微镜检查时，TCCE在TCZ治疗中观察到的寄生虫中的类似Tegumental改变，但在比较潜水期造成较大损伤，由肿胀，白斑，破坏的脑膜，脊椎丧失，导致侵蚀，病变和损失最终的Tegument中断。因此，通过最初导致Tegumental改变，TCCE可以对F.Gigantica施加其迷离作用。

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