...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Parasitology >Recombinant subunit vaccines for soil-transmitted helminths
【24h】

Recombinant subunit vaccines for soil-transmitted helminths

机译：用于土壤传播蠕虫的重组亚基疫苗

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Soil-transmitted helminths (STHs) collectively infect one fourth of all human beings, and themajority of livestock in the developing world. These gastrointestinal nematodes are the most important parasites on earth with regard to their prevalence in humans and livestock. Current anthelmintic drugs are losing their efficacies due to increasing drug resistance, particularly in STHs of livestock and drug treatment is often followed by rapid reinfection due to failure of the immune system to develop a protective response. Vaccines against STHs offer what drugs cannot accomplish alone. Because such vaccines would have to be produced on such a large scale, and be cost effective, recombinant subunit vaccines that include aminimumnumber of proteins produced in relatively simple and inexpensive expression systems are required. Here, we summarize all of the previous studies pertaining to recombinant subunit vaccines for STHs of humans and livestock with the goal of both informing the public of just how critical these parasites are, and to help guide future developments. Wealso discuss several key areas of vaccine development, which we believe to be critical for developing more potent recombinant subunit vaccines with broad-spectrum protection.
机译：土壤传播的蠕虫（StHS）集体感染了所有人类的四分之一，以及发展中国家的牲畜的主题。这些胃肠道线虫是地球上最重要的寄生虫关于他们在人类和牲畜中的患病率。目前，由于耐药性增加，目前的疾病是由于耐药性增加而导致的疗效，特别是在牲畜的STH和药物治疗中，通常由于免疫系统的失效而产生快速重新切换，以产生保护反应。针对StHS的疫苗提供什么药物无法单独完成。因为这些疫苗必须在这种大规模上产生，并且具有成本效益，因此需要包括在相对简单和廉价的表达系统中产生的蛋白质的蛋白质的重组亚基疫苗。在这里，我们总结了与重组亚基疫苗有关的所有先前研究，用于人类和牲畜的特性，其目标是通知公众的这些寄生虫是如何关键的，并帮助指导未来的发展。 Wealso讨论了疫苗开发的几个关键领域，我们认为对具有广谱保护的更有效的重组亚基疫苗至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号