Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art

Charlton Rebecca L.; Rossi-Bergmann Bartira; Denny Paul W.; Steel Patrick G.

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Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art

机译：作为发现新的反利尔诺的发现的策略：最先进的

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Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the genus Leishmania for which there is a paucity of effective viable non-toxic drugs. There are 1.3 million new cases each year causing considerable socioeconomic hardship, best measured in 2.4 million disability adjusted life years, with greatest impact on the poorest communities, which means that desperately needed new antileishmanial treatments have to be both affordable and accessible. Established medicines with cheaper and faster development times may hold the cure for this neglected tropical disease. This concept of using old drugs for new diseases may not be novel but, with the ambitious target of controlling or eradicating tropical diseases by 2020, this strategy is still an important one. In this review, we will explore the current state-of-the-art of drug repurposing strategies in the search for new treatments for leishmaniasis.

机译：Leishmaniaisis是由莱山岛属的原生动物寄生虫引起的矢量传播的热带病，其中缺乏有效的活性无毒药物。每年有130万新案例，造成相当大的社会经济困难，在240万残疾调整后的生活年份，对最贫穷的社区产生了最大的影响，这意味着迫切需要新的抗恋的治疗必须是价格实惠和可取的。具有更便宜和更快的发展时期的已建立药物可能对这种被忽视的热带疾病进行治愈。这种概念对新疾病的使用旧药物可能不是新颖的，但是，在2020年到2020年控制或消除热带疾病的雄心勃勃的目标，这种策略仍然是一个重要的目标。在这篇综述中，我们将探讨目前在寻找LeishManiaisis的新治疗中的药物修复策略。

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《Parasitology》 |2018年第2期|共18页
作者
Charlton Rebecca L.; Rossi-Bergmann Bartira; Denny Paul W.; Steel Patrick G.;
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作者单位

Univ Sci Labs Dept Chem South Rd Durham DH1 3LE England;

Univ Fed Rio de Janeiro Inst Biofis Carlos Chagas Filho BR-21949900 Rio De Janeiro RJ Brazil;

Univ Sci Labs Dept Biosci South Rd Durham DH1 3LE England;

Univ Sci Labs Dept Chem South Rd Durham DH1 3LE England;

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原文格式 PDF
正文语种 eng
中图分类寄生虫病;
关键词
leishmaniasis; repurposing; repositioning; drug discovery;

机译：Leishmaniaisis;重新调整;重新定位;药物发现;

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专利

1. Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art [J] . Charlton Rebecca L., Rossi-Bergmann Bartira, Denny Paul W., Parasitology . 2018,第2期

机译：作为发现新的反利尔诺的发现的策略：最先进的
2. Repurposing existing drugs for new AMPK activators as a strategy to extend lifespan: a computer-aided drug discovery study [J] . Mofidifar Sepideh, Sohraby Farzin, Bagheri Milad, Biogerontology . 2018,第2期

机译：将现有的新AMPK激活因素重新培养为延长寿命的策略：计算机辅助药物发现研究
3. Repurposing strategies for tropical disease drug discovery [J] . Klug Dana M., Gelb Michael H., Pollastri Michael P. Bioorganic and Medicinal Chemistry Letters . 2016,第11期

机译：重新利用热带疾病药物发现的策略
4. ANTICANCER POTENTIAL OF PHYTOCONSTITUENTS MODULATING NA/K ATPASE PUMP;A NOVEL REPURPOSING STRATEGY [C] . S.Jubie, M.Suresh Kumar, Niladri Sana Conference on Drug Design and Discovery Technologies . 2020

机译：植物试剂调节NA / K ATP酶泵的抗癌潜力;一种新的重新播放策略
5. Design, Synthesis, and Evaluation of Drugs Repurposed for Infectious Disease Drug Discovery [D] . Spaulding, Andrew E. 2018

机译：用于传染病药物发现的药物的设计，合成和评估
6. Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art [O] . REBECCA L. CHARLTON, BARTIRA ROSSI-BERGMANN, PAUL W. DENNY, -1

机译：重新定位为发现新的抗利什曼病毒的策略：最新技术
7. Repurposing as a strategy for the discovery of new anti-leishmanials : the-state-of-the-art. [O] . Charlton Rebecca, Rossi-Bergmann Bartira, Denny Paul W., 2017

机译：旨在将其作为发现新的反利什曼病毒的策略：最先进的技术。

Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art

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