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Microbial protein targets: towards understanding and intervention

机译：微生物蛋白目标：了解和干预

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The rise of antimicrobial resistance, coupled with a lack of industrial focus on antimicrobial discovery over preceding decades, has brought the world to a crisis point. With both human and animal health set to decline due to increased disease burdens caused by near untreatable microbial pathogens, there is an urgent need to identify new antimicrobials. Central to this is the elucidation of new, robustly validated, drug targets. Informed by industrial practice and concerns, the use of both biological and chemical tools in validation is key. In parallel, repurposing approved drugs for use as antimicrobials may provide both new treatments and identify new targets, whilst improved understanding of pharmacology will help develop and progress good 'hits' with the required rapidity. In recognition of the need to increase research efforts in these areas, in 14-16 September 2017, the British Society for Parasitology (BSP) Autumn Symposium was hosted at Durham University with the title: Microbial Protein Targets: towards understanding and intervention. Staged in collaboration with the Royal Society of Chemistry (RSC) Chemistry Biology Interface Division (CBID), the core aim was to bring together leading researchers working across disciplines to imagine novel approaches towards combating infection and antimicrobial resistance. Sessions were held on: 'Anti-infective discovery, an overview'; 'Omic approaches to target validation'; 'Genetic approaches to target validation'; 'Drug target structure and drug discovery'; 'Fragment-based approaches to drug discovery'; and 'Chemical approaches to target validation'. Here, we introduce a series of review and primary research articles from selected contributors to the Symposium, giving an overview of progress in understanding antimicrobial targets and developing new drugs. The Symposium was organized by Paul Denny (Durham) for the BSP and Patrick Steel (Durham) for RSC CBID.
机译：抗菌性抗性的兴起，加上缺乏工业关注于前几十年的抗菌发现，使世界带来了危机点。由于近乎无法治疗的微生物病原体接近疾病的疾病负担增加，人类和动物健康都会下降，迫切需要鉴定新的抗微生物剂。核心至关重要的是阐明新的，强大的验证的药物目标。通过工业实践和担忧了解，使用生物和化学工具在验证中是关键。并行，重新批准用于抗微生物的批准药物可以提供新的治疗方法并确定新的目标，同时提高了对药理学的理解将有助于发展和进展良好的“命中”。为了认识到需要提高这些领域的研究努力，2017年9月14日至14日，英国寄生虫学会（BSP）秋季研讨会在达勒姆大学举办了标题：微生物蛋白目标：用于了解和干预。与皇家化学学会（RSC）化学生物学界面师（CBID）进行分阶段，核心目标是将跨学科的领导研究人员汇集在一起​​，以想象新的对抗感染和抗微生物抗性的方法。会议被举行：'抗感染性发现，概述'; “目标验证的OMIC方法”; '目标验证的遗传方法'; “药物目标结构和药物发现”; “基于片段的药物发现方法”;和“目标验证的化学方法”。在这里，我们向专题讨论会的选定贡献者介绍了一系列评论和主要研究文章，概述了了解抗微生物目标和开发新药的进展。专题讨论会由Paul Denny（Durham）组织的BSP和Patrick钢（Durham）用于RSC CBID。

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