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DNA barcoding of Cryptosporidium

机译：DNA条形码加密孢子虫

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摘要

Cryptosporidium spp. (Apicomplexa) causing cryptosporidiosis are of medical and veterinary significance. The genus Cryptosporidium has benefited from the application of what is considered a DNA-barcoding approach, even before the term ‘DNA barcoding’ was formally coined. Here, the objective to define the DNA barcode diversity of Cryptosporidium infecting mammals is reviewed and considered to be accomplished. Within the Cryptosporidium literature, the distinction between DNA barcoding and DNA taxonomy is indistinct. DNA barcoding and DNA taxonomy are examined using the latest additions to the growing spectrum of named Cryptosporidium species and within-species and between-species identity is revisited. Ease and availability of whole-genome DNA sequencing of the relatively small Cryptosporidium genome offer an initial perspective on the intra-host diversity. The opportunity emerges to apply a metagenomic approach to purified field/clinical Cryptosporidum isolates. The outstanding question remains a reliable definition of Cryptosporidium phenotype. The complementary experimental infections and metagenome approach will need to be applied simultaneously to address Cryptosporidium phenotype with carefully chosen clinical evaluations enabling identification of virulence factors.
机译：Cryptosporidium spp。 （ApiCoMplexa）引起隐孢子虫病的医学和兽医意义。甚至在术语“DNA条形码”正式涂覆之前，该孢子虫属的应用甚至被认为是DNA-条形码方法的应用。这里，综述并考虑定义密码孢子虫哺乳动物的DNA条形码多样性的目的。在隐孢子虫文献中，DNA条形码和DNA分类物之间的区别是模糊的。使用最新的添加到名为Cryptimium物种的生长谱和物种内部和物种之间重新审查了DNA条形编码和DNA分类法。相对小的隐孢子虫基因组的全基因组DNA测序的缓解和可用性提供了对宿主内多样性的初始视角。机会出现了应用纯化田间/临床密码孢子酸盐分离物的偏见方法。突出问题仍然是隐孢子虫表型的可靠定义。互补的实验感染和偏见方法需要同时应用，以解决仔细选择的临床评估，以解决毒力因子的临床评估。

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