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Leishmaniasis: current challenges and prospects for elimination with special focus on the South Asian region

机译：利什曼病：目前在南亚地区特别关注的消除挑战和前景

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摘要

Leishmania donovani, the most virulent species of Leishmania, is found in the South Asian region that harbours the majority of visceral leishmaniasis (VL) cases in the world. The traditionally accepted relationships between the causative species of Leishmania and the resultant disease phenotype have been challenged during recent years and have underscored the importance of revisiting the previously established taxonomy with revisions to its classification. The weak voice of the afflicted with decades of neglect by scientists and policy makers have led to the miserably inadequate and slow advancements in product development in the fields of diagnostics, chemotherapeutics and vector control that continue to hinder the effective management and control of this infection. Limitations notwithstanding, the regional drive for the elimination of VL initiated over a decade ago that focused on India, Nepal and Bangladesh, the three main afflicted countries in the Indian subcontinent is therefore, commendable, with the subsequent status reviews and restructuring of strategies possibly even more so. However, the renewed efforts would need to be combined with plans to combat new challenges in the South-Asian region that includes the emergence of atypical parasite variants, in order to realistically achieve the set goal of regional elimination of VL.
机译：Leishmania Donovani是Leishmania最具毒性的物种，位于南亚地区，在世界上有大多数内脏的LeishManiaisis（VL）案件。在近年来，Leishmania的致病种和所得疾病表型的致病种与所得疾病表型之间的传统上接受的关系受到挑战，并强调了重新审视以前建立的分类对其分类的重新定位的重要性。科学家和政策制定者几十年的疏忽贫困人士的声音导致了诊断，化学治疗剂和载体控制领域的产品开发的惨剧性和缓慢的进步，这继续阻碍这种感染的有效管理和控制。尽管存在局限性，但在十年前取消了VL的区域驱动，重点是印度，尼泊尔和孟加拉国，这是印度次大陆的三个主要患有国家，因此，随后的状态审查和策略的重组可能是甚至的那么。然而，重新努力需要与打击南亚地区的新挑战的计划相结合，该区域包括出现非典型寄生虫变体的出现，以便实际实现区域消除VL的设定目标。

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