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首页> 外文期刊>Parasitology >Immune complex detection in saliva samples: an innovative proposal for the diagnosis of human strongyloidiasis
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Immune complex detection in saliva samples: an innovative proposal for the diagnosis of human strongyloidiasis

机译：唾液样本中的免疫复合物检测：一种诊断人抗肌腱病的创新建议

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摘要

Human strongyloidiasis is caused by helminth Strongyloides stercoralis. It has a worldwide distribution, often neglected and cause of severe morbidity. The parasitological diagnosis is hindered by the low and irregular amount of larvae in feces. The goal of the present study was to detect IgG and IgG immune complex using conventional serum samples and saliva as alternative samples. We collected samples from 60 individuals, namely: group I composed of 30 healthy individuals; and group II composed of 30 individuals eliminating S. stercoralis larvae in feces. We calculated the area under the curve, general index of diagnostic accuracy, Kappa index and determined the correlations between different diagnostic tests. The detection of IgG levels was performed by an immunoenzymatic assay with alkaline extract of S. venezuelensis larvae as antigen. Positivity of anti-S. stercoralis IgG in serum samples from group I was 3·3%, and from group II 93·3%. The detection of immune complex indicated that group I exhibited 3·3% and group II 56·7%. In the saliva samples, IgG detection was 26·7% for group I and 43·3% for group II. Immune complex was detected in 20% of group I, and 30% of group II. IgG immune complex in conventional serum samples and saliva as alternative samples can be considered biomarkers for the diagnosis of active strongyloidiasis.
机译：人氏化的肌腱病是由Helminth酮氏菌氏菌引起的。它具有全球分布，通常被忽视和严重发病率的原因。寄生学诊断受到粪便中的低和不规则量的幼虫。本研究的目的是使用常规血清样品和唾液检测IgG和IgG免疫复合物作为替代样品。我们收集了60名个人的样品，即：我由30名健康个人组成;和II组由30名粪便中的30人组成。我们计算了曲线下的面积，诊断准确性的一般指标，κ指数，并确定了不同诊断测试之间的相关性。通过用S. venezuelensis幼虫的碱性提取物作为抗原的免疫酶测定法进行IgG水平的检测。反速度的积极性。血清血清样品中的Stercoralis IgG为3·3％，并从II组93·3％。免疫复合物的检测表明，I族表现出3·3％和II组56·7％。在唾液样品中，IgG检测为IgⅠ组和II组的43·3％。在I组I的20％和30％的II％中检测到免疫复合物。常规血清样品和唾液中的IgG免疫复合物作为替代样品可以被认为是用于诊断活性抗硫化物的生物标志物。

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