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首页> 外文期刊>Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies >Multiple Organ Dysfunction in Children Mechanically Ventilated for Acute Respiratory Failure*
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Multiple Organ Dysfunction in Children Mechanically Ventilated for Acute Respiratory Failure*

机译：用于急性呼吸衰竭机械通风的儿童的多器官功能障碍*

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Measurements and Main Results: Organ dysfunction was defined using criteria published for pediatric sepsis. Multiple organ dysfunction syndrome was defined as respiratory dysfunction one or more extrapulmonary organ dysfunctions. We used multivariable logistic regression to identify risk factors for multiple organ dysfunction syndrome, and logistic or proportional hazards regression to compare clinical outcomes. All analyses accounted for PICU as a cluster variable. Overall, 73% exhibited extrapulmonary organ dysfunction, including 1,547 (63%) with concurrent multiple organ dysfunction syndrome defined by onset on day 0/1 and 244 (10%) with new multiple organ dysfunction syndrome with onset on day 2 or later. Most patients (93%) with indirect lung injury from sepsis presented with concurrent multiple organ dysfunction syndrome, whereas patients with direct lung injury had both concurrent (56%) and new (12%) multiple organ dysfunction syndrome. Risk factors for concurrent multiple organ dysfunction syndrome included older age, illness severity, sepsis, cancer, and moderate/severe lung injury. Risk factors for new multiple organ dysfunction syndrome were moderate/severe lung injury and neuromuscular blockade. Both concurrent and new multiple organ dysfunction syndrome were associated with 90-day in-hospital mortality (concurrent: adjusted odds ratio, 6.54; 95% CI, 3.00-14.25 and new: adjusted odds ratio, 3.21; 95% CI, 1.48-6.93) after adjusting for sepsis, moderate/severe lung injury, and other baseline characteristics.
机译：测量和主要结果：使用公开的儿科败血症的标准定义器官功能障碍。多器官功能障碍综合征定义为呼吸功能障碍一个或多个外肺器官功能障碍。我们使用多变量的逻辑回归来识别多器官功能障碍综合征的风险因素，以及对比较临床结果的物流或比例危害回归。所有分析都占PICU作为群集变量。总体而言，73％表现出外肺器官功能障碍，包括1,547％（63％），并在第0/1天和第244天（10％）上定义的同时的多器官功能障碍综合征，其中具有新的多器官功能障碍综合征，第2天或更高的发作。大多数患者（93％）（93％）来自败血症的间接肺损伤，伴有并发多器官功能障碍综合征，而直接肺损伤的患者同时（56％）和新（12％）多器官功能障碍综合征。并发多器官功能障碍综合征的危险因素包括较老年龄，疾病严重程度，脓毒症，癌症和中度/严重肺损伤。新多器官功能障碍综合征的危险因素是中度/严重的肺损伤和神经肌肉阻滞。并发和新的多器官功能障碍综合征与90天的住院内死亡率相关联（并发：调整后的赔率比，6.54; 95％CI，3.00-14.25和新：调整后的赔率比，3.21; 95％CI，1.48-6.93 ）调整败血症，中度/严重肺损伤和其他基线特征后。

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