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首页> 外文期刊>Pediatric diabetes. >Characteristics of cystic fibrosis‐related diabetes: Data from two different sources the European cystic fibrosis society patient registry and German/Austrian diabetes prospective follow‐up registry
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Characteristics of cystic fibrosis‐related diabetes: Data from two different sources the European cystic fibrosis society patient registry and German/Austrian diabetes prospective follow‐up registry

机译：囊性纤维化相关糖尿病的特征：来自两种不同来源的数据欧洲囊性纤维化协会患者登记处和德国/奥糖尿病预期后续登记处

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Background Standardized patient registries provide a unique basis to get insight into cystic fibrosis (CF)‐related diabetes (CFRD), the most common comorbidity in CF. Methods A total of 3853 CFRD patients from the European CF Society Patient Registry (ECFSPR) and 752 from the German/Austrian diabetes prospective follow‐up (diabetes patienten verlaufsdokumentation [DPV]) were studied. To adjust for age and sex, multivariable regression was used (SAS 9.4). Results DPV subjects were younger (26.5 [20.2‐32.6] vs 28.3 [21.7‐36.0] years, P ??0.001) and more often female (59.6 vs 50.9%, P ??0.001). In both registries, F508del homozygotes were most frequent, with higher proportion in DPV (80.9 vs 57.8%, P ?=?0.003). After adjustment, lung‐transplantation (LTX) was more common in ECFSPR (18.9 vs 4.9%, P ??0.001), although duration since LTX (4.8?±?0.2 vs 5.5?±?0.7?years, P ?=?0.33) did not differ. In DPV patients without LTX, a lower BMI (19.6?±?0.1 vs 21.0?±?0.1 kg/m 2 , P ??0.001), higher proportion of underweight (41.2 vs 20.2%, P ??0.001) and a tendency towards worse lung function (%FEV 1 : 42.3?±?4.2 vs 48.3?±?0.5%, P ?=?0.16) were observed. Conclusions Between both registries, demographic and clinical differences of CFRD were present. Besides different kind of data sources, diverse treatment structures between countries may play a role. The results may further indicate a more serious illness in patients treated in specialized diabetes clinics, documenting their data in DPV.
机译：背景技术标准化患者注册表提供了独特的基础，以了解囊性纤维化（CF）相关糖尿病（CFRD），CF中最常见的合并症。方法研究欧洲CF社会患者登记处（ECFSPR）的3853名CFRD患者和752名来自德国/奥地利糖尿病的前瞻性随访（糖尿病患者Verlaufsdokumentation [DPV]）。为了调整年龄和性别，使用多变量的回归（SAS 9.4）。结果DPV受试者年轻（26.5 [20.2-32.6] Vs 28.3 [21.7-36.0]岁，p？0.001），更常见的（59.6 Vs 50.9％，p≤≤0.001）。在两个注册表中，F508del纯合子最常见，DPV比例较高（80.9 Vs 57.8％，p？= 0.003）。在调整后，肺移植（LTX）在ECFSPR中更常见（18.9 Vs 4.9％，p≤≤0.001），尽管LTX（4.8？±0.2 Vs 5.5？±0.7？岁，P？= ？0.33）没有差异。在没有LTX的DPV患者中，低BMI（19.6？±0.1Vs 21.0？±0.1 kg / m 2，p≤≤0.001），更高的体重比例（41.2 vs 20.2％，p≤0.001 ）观察到肺功越差的趋势（％FEV 1：42.3？±4.2 vs 48.3？±0.5％，p？= 0.16）。目前出现了注册管理资源，人口统计学和临床​​差异的结论。除了不同类型的数据源，各国之间的各种治疗结构可能发挥作用。结果可以进一步表明在专用糖尿病诊所治疗的患者中更严重的疾病，记录其在DPV中的数据。

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