...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pediatric diabetes. >Subclinical arterial damage in children and adolescents with type 1 diabetes: A systematic review and meta‐analysis
【24h】

Subclinical arterial damage in children and adolescents with type 1 diabetes: A systematic review and meta‐analysis

机译：患有1型糖尿病儿童和青少年的亚临床动脉损伤：系统评价和荟萃分析

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Background and Objective Type 1 diabetes is an important risk factor for the development of cardiovascular disease. Pulse wave velocity (PWV) and carotid intima‐media thickness (cIMT) measurements are well recognized as independent predictors for future cardiovascular disease. The aim of the present study was to systematically review the literature and conduct a meta‐analysis assessing measures of subclinical arterial damage in children and adolescents with type 1 diabetes in comparison to healthy controls. Methods PubMed and Cochrane Library were searched to identify studies comparing cIMT and carotid‐femoral PWV levels between children with type 1 diabetes and healthy controls. Meta‐analysis was performed to compare the difference of overall mean cIMT and carotid‐femoral PWV levels between the two groups. New Castle Ottawa quality assessment scale for case‐control studies was used to assess study quality. Results Twenty‐three studies were finally included in the meta‐analysis (20 studies for cIMT and 4 studies for carotid‐femoral PWV). Youth with type 1 diabetes had significantly higher cIMT levels than controls (mean difference [ d ] = 0.03, 95% confidence interval [CI] = 0.02‐0.04), as well as higher carotid‐femoral PWV levels ( d = 0.26, 95% CI = 0.18‐0.34). Heterogeneity was present only in the cIMT analysis ( I 2 ??90%). Conclusions Youth with type 1 diabetes showed signs of subclinical arterial damage, as suggested by higher levels of cIMT and carotid‐femoral PWV compared to healthy controls at childhood and adolescence. Preventive and therapeutic interventions early in course of disease may be further studied to decrease morbidity in this high‐risk young patient group. PROSPERO registration number: 2018 CRD42018094354.
机译：抽象背景和目的类型1糖尿病是心血管疾病发展的重要危险因素。脉搏波速度（PWV）和颈动脉内膜介质厚度（CIMT）测量得到很好的认可作为未来心血管疾病的独立预测因子。本研究的目的是系统地审查文献，并对健康对照进行糖尿病患者和青少年的亚临床动脉损伤的荟萃分析评估措施。方法搜索了PubMed和Cochrane库，鉴定了比较1型糖尿病和健康对照组中儿童的CIMT和颈动脉患者PWV水平的研究。进行了META分析以比较两组之间的总体平均CIMT和颈动脉股PWV水平的差异。新城堡渥太华质量评估规模用于案例控制研究，用于评估研究质量。结果23项研究最终包括在META分析中（20个CIMT研究和4种颈动脉股PWV的研究）中。 1型糖尿病的青少年的CIMT水平明显高于对照（平均差异[D] = 0.03,95％置信区间[CI] = 0.02-0.04），以及更高的颈动脉股PWV水平（D = 0.26,95％ CI = 0.18-0.34）。异质性仅存在于CIMT分析中（I 2？＆ 90％）。结论青少年患有1型糖尿病显示亚临床动脉损伤的迹象，如较高水平的CIMT和颈动脉股PWV所提出的，与儿童时期和青春期的健康对照相比。可能进一步研究疾病早期预防和治疗干预，以降低这种高危年轻患者组中的发病率。 Prospero注册号：2018年CRD42018094354。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号