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Neuropathic Pain in Pediatric Oncology: A Clinical Decision Algorithm

机译:儿科肿瘤学的神经性疼痛:一种临床决策算法

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摘要

Neuropathic pain in pediatric oncology can be caused by distinct lesions or disease processes affecting the somatosensory system, including chemotherapy-related neuronal injury, solid tumor-related involvement of neural structures, post-surgical neuropathic painincluding phantom limb pain and pain after limb-sparing surgeryand the complex circumstances of neuropathic pain at the end of life. Treatment algorithms reflect the general treatment principles applied for adult neuropathic pain, but the dose regimens applied in children are modest and rarely escalated to the maximum doses to optimize analgesic efficacy. Pharmacological management of neuropathic pain should be based on a stepwise intervention strategy, as combinations of medications are the most effective approach. Gabapentinoids and tricyclic antidepressants are recommended as first-line therapy. Methadone, ketamine, and lidocaine may be useful adjuvants in selected patients. Prospective studies extended over a substantial length of time are recommended because of the nature of neuropathic pain as persistent, chronic pain and based on the need for sufficient time to escalate medication dose regimens to full analgesic efficacy.
机译:儿科肿瘤的神经疗法疼痛可能是由影响躯体感觉体系的不同病变或疾病过程引起的,包括化疗相关的神经元损伤,与神经结构的实体瘤相关的患者,手术后神经治疗后肢体肢体疼痛和肢体稀疏疼痛和肢体稀疏的外科疼痛疼痛生命结束时神经性疼痛的复杂情况。治疗算法反映了对成年神经病疼痛施用的一般治疗原理,但在儿童中施用的剂量方案是适度的,并且很少升级到最大剂量以优化镇痛功效。神经性疼痛的药理管理应基于逐步干预策略,因为药物的组合是最有效的方法。甘蓝产脂蛋白和三环抗抑郁药被推荐为一线疗法。美沙酮,氯胺酮和利多卡因可能是选定患者中有用的佐剂。由于神经性疼痛的性质,持续,慢性疼痛,并且基于足够的时间将药物剂量方案升高到全镇痛效果,建议延长大量时间的前瞻性研究。

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  • 来源
    《Pediatric drugs》 |2019年第2期|共12页
  • 作者单位

    St Jude Childrens Res Hosp Dept Pediat Med Div Anesthesia Mail Stop 130 262 Danny Thomas Pl;

    St Jude Childrens Res Hosp Dept Pediat Med Div Anesthesia Mail Stop 130 262 Danny Thomas Pl;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

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