The Immune Microenvironment in Breast Carcinoma: Predictive and Prognostic Role in the Neoadjuvant Setting

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The Immune Microenvironment in Breast Carcinoma: Predictive and Prognostic Role in the Neoadjuvant Setting

机译：乳腺癌中的免疫微环境：新辅助设定中的预测和预测作用

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The prognostic value of the immune cell infiltrate in the breast carcinoma microenvironment is still uncertain. We reviewed published articles analysing the infiltration of inflammatorycells in the microenvironment of breast carcinoma. Data revealed the importance of infiltration of these immune cells in the prognosis of breast carcinoma, particularly the triple-negative and HER2-positive phenotypes. Tumour-infiltrating lymphocytes and their subtypes play a fundamental role in predicting the pathological complete response (pCR) to neoadjuvant chemotherapy. More research aiming to dissect a complex network of communication between cancer cells and other cellular components of the tumour microenvironment is necessary to develop more effective therapeutic approaches.

机译：乳腺癌微环境中免疫细胞浸润的预后值仍然不确定。我们审查了已发表的文章，分析了乳腺癌微环境中炎性细胞的渗透。数据揭示了乳腺癌预后渗透这些免疫细胞的重要性，特别是三阴性和HER2阳性表型。肿瘤浸润淋巴细胞及其亚型在预测新辅助化疗的病理完全反应（PCR）中起着基本作用。需要对癌细胞和肿瘤微环境的其他细胞组分进行描述的更多研究是开发更有效的治疗方法。

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《Pathobiology: journal of immunopathology, molecular and cellular biology》 |2020年第2期|共14页
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正文语种 eng
中图分类病理学;
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Breast carcinoma; Tumour-infiltrating lymphocytes; Neoadjuvant chemotherapy; Tumour-infiltrating macrophages; Tumour-infiltrating neutrophils; Tumour-infiltrating dendritic cells; Pathological complete response;

机译：乳腺癌;肿瘤浸润淋巴细胞;Neoadjuvant化疗;肿瘤浸润巨噬细胞;肿瘤浸润的中性粒细胞;肿瘤浸润的树突细胞;病理完全反应;

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专利

1. The Immune Microenvironment in Breast Carcinoma: Predictive and Prognostic Role in the Neoadjuvant Setting [J] . Pathobiology: journal of immunopathology, molecular and cellular biology . 2020,第2期

机译：乳腺癌中的免疫微环境：新辅助设定中的预测和预测作用
2. Predictive and Prognostic Role of Tumor-Infiltrating Lymphocytes for Early Breast Cancer According to Disease Subtypes: Sensitivity Analysis of Randomized Trials in Adjuvant and Neoadjuvant Setting [J] . Carbognin Luisa, Pilotto Sara, Nortilli Rolando, The oncologist . 2016,第3期

机译：根据疾病亚型，肿瘤浸润淋巴细胞对早期乳腺癌的预测和预后作用：佐剂和新佐剂环境中随机试验的敏感性分析
3. Predictive and Prognostic Role of Tumor-Infiltrating Lymphocytes for Early Breast Cancer According to Disease Subtypes: Sensitivity Analysis of Randomized Trials in Adjuvant and Neoadjuvant Setting [J] . Luisa Carbognin, Sara Pilotto, Rolando Nortilli, The oncologist . 2016,第3期

机译：根据疾病亚型，肿瘤浸润淋巴细胞对早期乳腺癌的预测和预后作用：佐剂和新佐剂环境中随机试验的敏感性分析
4. Immunohistochemistry applications in breast carcinoma: The Hypoxia Inducible Factor lα, Estrogen Receptor, Progesterone Receptor and HER2 expression before and after neoadjuvant chemotherapy [C] . Zuofeng Zhang, Yunai Liang, Chunhua Zhang, Technical Congress on Resources, Environment and Engineering . 2016

机译：免疫组织化学在乳腺癌中的应用：缺氧诱导因子Lα，雌激素受体，孕酮受体和Neoadjuvant化疗前后和Her2表达
5. Role of Protein Tyrosine Kinase 6 in the Immune Microenvironment of Triple Negative Breast Cancer Cells [D] . Eden, Caroline. 2018

机译：蛋白酪氨酸激酶6在三重阴性乳腺癌细胞免疫微环境中的作用
6. Predictive and Prognostic Role of Tumor-Infiltrating Lymphocytes for Early Breast Cancer According to Disease Subtypes: Sensitivity Analysis of Randomized Trials in Adjuvant and Neoadjuvant Setting [O] . Luisa Carbognin, Sara Pilotto, Rolando Nortilli, 2016

机译：根据疾病亚型肿瘤浸润淋巴细胞对早期乳腺癌的预测和预后作用：佐剂和新佐剂环境中随机试验的敏感性分析
7. Predictive and Prognostic Role of Tumor‐Infiltrating Lymphocytes for Early Breast Cancer According to Disease Subtypes: Sensitivity Analysis of Randomized Trials in Adjuvant and Neoadjuvant Setting [O] . Luisa Carbognin, Sara Pilotto, Rolando Nortilli, 2016

机译：患有疾病亚型肿瘤患者早期乳腺癌的预测性和预测作用：佐剂和新辅助设定随机试验的敏感性分析

The Immune Microenvironment in Breast Carcinoma: Predictive and Prognostic Role in the Neoadjuvant Setting

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