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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Differential Expression of Cancer-Associated Fibroblast-Related Proteins in Ductal Carcinoma in situ According to Molecular Subtype and Stromal Histology
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Differential Expression of Cancer-Associated Fibroblast-Related Proteins in Ductal Carcinoma in situ According to Molecular Subtype and Stromal Histology

机译：根据分子亚型和基质组织学原位癌症相关成纤维细胞相关蛋白的差异表达

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Objective: The purpose of this study is to investigate the expression of cancer-associated fibroblast (CAF)-related proteins and their implication in ductal carcinoma in situ (DCIS). Methods: We constructed a tissue microarray of 223 cases of DCIS and examined immunohistochemical staining for the 7 CAF-related proteins. We classified DCIS into luminal type, human epidermal growth factor receptor-2 (HER-2) type, and triple negative breast cancer (TNBC) according to the immunohistochemical results for estrogen receptor, progesterone receptor, and HER-2. We also classified DCIS into desmoplastic, normal-like, and inflammatory type according to stromal histology. Results: There were significant differences in the expression of S100A4, podoplanin, prolyl 4-hydroxylase subunit alpha 3, NG2, and PDGFR in stromal cells of DCIS when classified according to molecular subtype. The expression rate of all CAF-related proteins in stromal cells was higher in the HER-2 type and TNBC than in the luminal type (p 0.001). When classified according to stromal subtype, there were significant differences in the expression of all CAF-related proteins in stromal cells, with the inflammatory stromal type showing higher expression of CAF-related proteins than other stromal types. Conclusion: The expression of CAF-related proteins in stromal cells of DCIS varies according to molecular subtype and stromal type.
机译：目的：本研究的目的是探讨癌症相关成纤维细胞（CAF）相关蛋白的表达及其在原位（DCIS）的导管癌中的含义。方法：我们构建了223例DCI患者的组织微阵列，并检查了7个CAF相关蛋白的免疫组化染色。根据雌激素受体，孕酮受体和HER-2的免疫组化结果，我们将DCIS分为腔式，人表皮生长因子受体-2（HER-2）型和三重阴性乳腺癌（TNBC）。我们还根据基质组织学分配DCIS进入DESMOPLACT，正常状和炎症类型。结果：根据分子亚型分类，S100A4，Podoplanin，吡吡l4-羟化酶亚基α3，NG2和PDGFR在DCIS的基质细胞中存在显着差异。在腔型中，SHER-2型和TNBC中所有CAF相关蛋白质中所有CAF相关蛋白的表达率较高（P <0.001）。当根据基质亚型分类时，基质细胞中所有CAF相关蛋白的表达存在显着差异，具有炎症基质类型，显示出比其他基质类型的CAF相关蛋白表达更高。结论：DCIS基质细胞中CAF相关蛋白的表达根据分子亚型和基质类型而变化。

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