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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >Tumor Heterogeneity in Endometrial Carcinoma: Practical Consequences
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Tumor Heterogeneity in Endometrial Carcinoma: Practical Consequences

机译：子宫内膜癌中的肿瘤异质性：实际后果

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摘要

Endometrial carcinoma (EC) shows intertumor heterogeneity, with several different histologic types differing in their morphologic and molecular features. There is also intratumoral morphologic heterogeneity, with different neoplastic cell components within the same tumor, with different morphologic and molecular features. In this article, we discuss the consequences of tumor heterogeneity in EC at the morphologic and molecular levels, by describing some illustrative examples produced by the research team. They are (1) morphologic heterogeneity in conventional EC and mixed tumors, (2) EC with microsatellite instability, (3) branched evolution as shown by exome sequencing analysis, (4) morphologic, molecular, and metabolomic differences between the tumor surface and myometrial invasion front, (5) tumor heterogeneity at the microenviromental level, (6) the sensitivity of endometrial aspirates to detect tumor heterogeneity in EC, and (7) sampling strategies to detect tumor heterogeneity in hysterectomy specimens. Tumor heterogeneity may have an important clinical impact, since it can be challenging to identify minor tumor cell populations that may have an impact on diagnosis, prognosis, and therapeutic decisions for patients with EC. (C) 2017 S. Karger AG, Basel.
机译：子宫内膜癌（EC）表示Intertumor异质性，其形态学和分子特征的几种不同的组织学类型不同。在同一肿瘤内具有不同肿瘤细胞组分的肿瘤内的形态学异质性，具有不同的形态学和分子特征。在本文中，我们通过描述研究团队生产的一些说明性示例，讨论EC在eC中肿瘤异质性的后果。它们是（1）常规EC和混合肿瘤中的形态异质性，（2）EC，微卫星不稳定性，（3）支链演化，如exome测序分析所示，（4）肿瘤表面与肌瘤之间的形态学，分子和代谢组差异。侵袭前部，（5）微生素血管水平的肿瘤异质性，（6）子宫内膜吸气的敏感性检测EC中的肿瘤异质性，（7）采样策略以检测子宫切除术样品中的肿瘤异质性。肿瘤异质性可能具有重要的临床影响，因为鉴定可能对欧共体患者的诊断，预后和治疗决策产生影响的轻微肿瘤细胞群可能是挑战性的。 （c）2017年S. Karger AG，巴塞尔。

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