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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >A Practical Approach to Tumor Heterogeneity in Clinical Research and Diagnostics
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A Practical Approach to Tumor Heterogeneity in Clinical Research and Diagnostics

机译：临床研究和诊断中肿瘤异质性的实用方法

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This Pathobiology issue tries to better define the complex phenomenon of intratumor heterogeneity (ITH), mostly from a practical point of view. This topic has been chosen because ITH is a central issue in tumor development and has to be investigated directly in patient tissue and immediately applied in the treatment of the presenting patient. Different types of ITH should be considered: clonal genetic and epigenetic evolution, morphological heterogeneity, and tumor sampling, heterogeneity resulting from microenvironmental autocrine and paracrine interaction, and stochastic plasticity related to different functional cell efficiencies. For a higher level of reproducibility in clinical research and diagnostics, it is necessary to establish standardized analytical methods, including microdissection. In situ techniques can be pivotal to explore tumor microenvironment and can be improved with associated digital analysis. Liquid biopsies for plasma DNA analysis are at present the best method to study recurrent tumors with treatment adaptation, and wide-spread clinical use could be beneficial. The different types of tumor genomic instabilities could have pragmatic applications to rank ITH for clinical applications: treatment approaches differ in patients with a high nucleotide mutation rate and patients with high copy number alterations. (C) 2017 S. Karger AG, Basel.
机译：这种病理化学问题试图更好地定义腹腔内异质性（ITH）的复杂现象，主要是从实际的角度来看。已经选择了这一主题，因为ITH是肿瘤发育中的核心问题，并且必须直接在患者组织中进行研究，并立即在治疗患者的治疗中进行。应考虑不同类型的ITH：克隆遗传和表观遗传演化，形态异质性和肿瘤取样，由微环境自分泌和旁节静脉相互作用导致的异质性，以及与不同功能细胞效率相关的随机塑性。对于临床研究和诊断中的更高水平的可重复性，有必要建立标准化的分析方法，包括显微切割。原地技术可以赋予探索肿瘤微环境，并且可以通过相关的数字分析来改善。血浆DNA分析的液体活组织检查目前目前研究经常治疗适应性肿瘤的最佳方法，宽蔓延的临床用途可能是有益的。不同类型的肿瘤基因组稳定性可以具有务实的应用来对临床应用进行排名：治疗方法在具有高核苷酸突变率和高拷贝数改变的患者的患者中不同。 （c）2017年S. Karger AG，巴塞尔。

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