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首页> 外文期刊>Pathobiology: journal of immunopathology, molecular and cellular biology >The Multifaceted Nature of Tumor Microenvironment in Breast Carcinomas
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The Multifaceted Nature of Tumor Microenvironment in Breast Carcinomas

机译：乳腺癌中肿瘤微环境的多方面性质

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摘要

Heterogeneity in breast carcinomas can be appreciated at various levels, from morphology to molecular alterations, and there are well-known genotypic-phenotypic correlations. Clinical decision-making is strictly focused on the evaluation of tumor cells and is based on the assessment of hormone receptors and of the HER2 status, by means of a combination of immunohistochemical and in situ hybridization techniques. The tumor microenvironment (TME) also shows a multifaceted nature stemming from the different actors populating the intratumoral and the peritumoral stroma of breast carcinomas. Of note, we have now evidence that tumor-infiltrating lymphocytes (TILs) are clinically meaningful as their quantification in the intratumoral stroma strongly correlates with good prognosis, in particular in triple-negative and HER2-positive breast cancer patients. Nevertheless, TILs are just one of the many actors orchestrating the complexity of the TME, which is populated by immune and non-immune cells (cancer-associated fibroblasts, cancer-associated adipocytes), as well as non-cellular components such as chemical inflammation mediators. In this review article we will overview the main features of the distinct cell compartments by discussing (i) the potential impact the TME may have on the prognostic stratification of breast cancers and (ii) the possible predictive value of some markers in the context of immunotherapy in light of the recent results of phase III studies in advanced and early triple-negative breast cancer patients.
机译：可以在各种水平中理解乳腺癌中的异质性，从形态学到分子改变，并且存在着名的基因型 - 表型相关性。临床决策严格关注对肿瘤细胞的评估，并通过免疫组织化学和原位杂交技术的组合来基于激素受体和HER2状态的评估。肿瘤微环境（TME）还显示出从填充肿瘤癌的肿瘤内和Peritumoral基质的不同演员的多方面性质。值得注意的是，我们现在有证据表明肿瘤浸润的淋巴细胞（TIL）在脑内基质中的定量与良好预后的定量强烈相关，特别是在三阴性和HER2阳性乳腺癌患者中。尽管如此，TILS只是协调TME的复杂性的许多演员之一，其被免疫和非免疫细胞（癌症相关的成纤维细胞，癌症相关的脂肪细胞）以及非细胞组分如化学炎症调解员。在这篇审查文章中，我们将通过讨论（i）讨论TME可能对乳腺癌预后分层的潜在影响以及（ii）在免疫疗法的背景下的可能预测值的可能性影响鉴于最近在先进和早期三重阴性乳腺癌患者中的III期研究结果的结果。

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