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首页> 外文期刊>Pest Management Science >Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid (Myzus persicae and Macrosiphum rosae) stress tolerance
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Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid (Myzus persicae and Macrosiphum rosae) stress tolerance

机译：患神经肽结合位点的评估及生物稳态生物和CAP2B模拟处理对蚜虫（Myzus Persicae和Macrosiphum Rosae）应力耐受性的影响

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BACKGROUND Neuropeptides are regulators of critical life processes in insects and, due to their high specificity, represent potential targets in the development of greener insecticidal agents. Fundamental to this drive is understanding neuroendocrine pathways that control key physiological processes in pest insects and the screening of potential analogues. The current study investigated neuropeptide binding sites of kinin and CAPA (CAPA-1) in the aphids Myzus persicae and Macrosiphum rosae and the effect of biostable analogues on aphid fitness under conditions of desiccation, starvation and thermal (cold) stress. RESULTS M. persicae and M. rosae displayed identical patterns of neuropeptide receptor mapping along the gut, with the gut musculature representing the main target for kinin and CAPA-1 action. While kinin receptor binding was observed in the brain and VNC of M. persicae, this was not observed in M. rosae. Furthermore, no CAPA-1 receptor binding was observed in the brain and VNC of either species. CAP2b/PK analogues (with CAPA receptor cross-activity) were most effective in reducing aphid fitness under conditions of desiccation and starvation stress, particularly analogues 1895 (2Abf-Suc-FGPRLa) and 2129 (2Abf-Suc-ATPRIa), which expedited aphid mortality. All analogues, with the exception of 2139-Ac, were efficient at reducing aphid survival under cold stress, although were equivalent in the strength of their effect. CONCLUSION In demonstrating the effects of analogues belonging to the CAP2b neuropeptide family and key analogue structures that reduce aphid fitness under stress conditions, this research will feed into the development of second generation analogues and ultimately the development of neuropeptidomimetic-based insecticidal agents. (c) 2019 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
机译：背景技术神经肽是昆虫中临界生命过程的调节因素，并且由于它们的高特异性，代表着绿色杀虫剂的发展中的潜在目标。该驱动器的基础是了解神经内分泌途径，可控制害虫昆虫和潜在类似物的筛查中的关键生理过程。目前研究在蚜虫骨髓苷和麦克风植物中研究了Kinin和Capa（Capa-1）的神经肽结合位点，以及在干燥，饥饿和热（冷）应力的条件下生物沸腾类似物对蚜虫适应性的影响。结果M. persicae和M. rosae沿着肠道显示出神经肽受体映射的相同模式，肠道肌肉组织代表Kinin和Capa-1作用的主要靶标。虽然在M.Spericae的大脑和VNC中观察到Kinin受体结合，但在M. Rosae中未观察到这一点。此外，在任何种类的脑和VNC中观察到钙-1受体结合。 CAP2B / PK类似物（具有CAPA受体交叉活性）最有效地降低干燥和饥饿应激条件下的蚜虫适应性，特别是类似物的类似物1895（2ABF-SUC-FGPRLA）和2129（2ABF-SUC-ATPRIA），其加急蚜虫死亡。除了2139-AC外，所有类似物在减少冷应力下还原蚜虫存活率外，虽然它们的效果强度等同。结论在展示属于CAP2B神经肽家族的类似物和减少蚜虫条件下的关键模拟结构的类似物，这项研究将进入第二代类似物的发展，最终发展神经肽基杀虫剂的发展。 （c）2019年作者。害虫管理科学由John Wiley＆Sons Ltd发表代表化学工业社会。

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