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首页> 外文期刊>Pharmaceutical patent analyst >Therapeutic charm of quercetin and its derivatives: a review of research and patents
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Therapeutic charm of quercetin and its derivatives: a review of research and patents

机译：槲皮素的治疗性魅力及其衍生物：研究和专利综述

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摘要

Bioactive polyphenolic compounds derived from plants are being utilized for prevention of various chronic diseases including cancer and cardiovascular disorders. Quercetin, a potential poly-phenolic flavonol, found in onions, apples and berries, has been implicated against cancer proliferation, chronic inflammation and various other oxidative manifestations. Evidences suggested that quercetin negatively regulates the numerous crucial signaling pathways associated with life-threatening diseases. Major signaling pathways including NF-icB, MAPK, PBK-AKT and mTOR are found to be regulated by quercetin. In addition, several patents have reported recently on quercetin derivatives describing wide therapeutic applications such as anticancer/antiproliferatory, antioxidative/antiaging, antiviral, anti-inflammatory, cardioprotec-tive.
机译：衍生自植物的生物活性多酚化合物用于预防包括癌症和心血管疾病的各种慢性疾病。 槲皮素是洋葱，苹果和浆果中发现的潜在聚酚黄酮，含有癌症增殖，慢性炎症和各种其他氧化表现。 证据表明，槲皮素负面调节与危及生命疾病相关的许多关键信号途径。 发现包括NF-ICB，MAPK，PBK-AKT和MTOR的主要信令途径被槲皮素调节。 此外，几项专利最近报道了描述宽型治疗应用的槲皮素衍生物，例如抗癌/抗抗原性，抗氧化/抗氧化，抗病毒，抗炎，心肺蛋白酶。

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