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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Repeated administration of a selenium-containing indolyl compound attenuates behavioural alterations by streptozotocin through modulation of oxidative stress in mice
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Repeated administration of a selenium-containing indolyl compound attenuates behavioural alterations by streptozotocin through modulation of oxidative stress in mice

机译：反复施用含硒的吲哚基化合物通过链脲佐菌素通过调节小鼠的氧化胁迫来衰减行为改变

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Although the pathophysiology of major depression disorder (MDD) is still poorly understood, mounting evidence suggests that the brains of depressed patients are under oxidative stress, leading to depressive symptoms that may include anxiety and cognitive impairment. This study aimed to investigate if the seleno-organic compound 1-methyl-3-(phenylselanyl)-1H-indole (MFSeI) reverses the depression- and anxiogenic-like behaviour, cognitive impairment and oxidative stress induced by the infra-cerebroventricular injection of streptozotocin (STZ; 0.2 mg/4 mu l/per mouse) in Swiss male mice. Twenty-four hours after the STZ injection, mice were treated with MFSeI (10 mg/kg, intra-gastrically), or vehicle solution, once daily for seven days. The behavioural tests were performed 30 min after the final MFSeI administration, followed by euthanasia and collection of the cerebral cortex and hippocampus. Administration of MFSeI reversed the depression- and anxiogenic-like behaviour and cognitive impairment induced by STZ, in mice. Neurochemical analyses demonstrated that MFSeI reversed the STZ-increased levels of reactive species, nitrite, lipid peroxidation and acetylcholinesterase activity in the cerebral cortex and hippocampus of mice. Moreover, a single administration of MFSeI (300 mg/kg, intra-gastrically) did not cause acute toxicity in Swiss male mice. Altogether, our data suggest that MFSeI exhibits antidepressant and anxiolytic-like effects and improves the cognition of STZ-treated mice, without any toxicity.
机译：虽然重大抑郁症（MDD）的病理生理学仍然明白，但安装证据表明抑郁症患者的大脑在氧化应激上，导致可能包括焦虑和认知障碍的抑郁症状。该研究旨在研究Seleno-有机化合物1-甲基-3-（苯脲）-1H-吲哚（MFSeI）是否逆转了抑郁症和焦虑的行为，认知障碍和由红外线腔内注射引起的氧化胁迫链脲佐菌素（STZ; 0.2mg / 4 mu L / per mouse）在瑞士雄性小鼠中。 STZ注射后二十四小时，用MFSEI（10mg / kg，胃内胃）或载体溶液处理小鼠，每天七天处理。在最终MFSEI施用后30分钟进行行为试验，然后进行安乐死和脑皮质和海马的收集。 MFSei的管理逆转了STZ，小鼠诱导的抑郁症和焦虑的行为和认知障碍。神经化学分析表明，MFSEI在脑皮层和小鼠海马中逆转了活性物质，亚硝酸盐，脂质过氧化和乙酰胆碱酯酶活性的STZ增加水平。此外，单一施用MFSEI（300mg / kg，胃内胃）在瑞士雄性小鼠中没有引起急性毒性。完全，我们的数据表明，MFSEI表现出抗抑郁药和抗焦虑的效果，并改善了STZ处理的小鼠的认知，而没有任何毒性。

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