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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Delta-9-THC exposure during zebra finch sensorimotor vocal learning increases cocaine reinforcement in adulthood
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Delta-9-THC exposure during zebra finch sensorimotor vocal learning increases cocaine reinforcement in adulthood

机译：Zebra Finch Serverimotor声乐学习期间的Delta-9-THC暴露在成年期增加了可卡因加强

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摘要

Zebra finches are songbirds that learn vocal patterns during a sensitive period of development that approximates adolescence. Exposure of these animals to a cannabinoid agonist during their period of sensorimotor vocal learning alters song patterns produced in adulthood. Thus, songbirds have unique value in studying developmental effects of drug exposure on a naturally learned behavior. A missing feature of this animal model has been a method to study drug reinforcement of behavior. To address this gap we have adapted place conditioning methods, used previously to determine that singing behavior is rewarding, to study cocaine reinforcement of behavior. We have found that cocaine dose-dependently reinforces both place conditioning and aversion at potencies consistent with those observed in mammalian species. Use of this place conditioning method has allowed us to determine that, when administered during periods of sensorimotor vocal learning, delta-9-THC, but not nicotine persistently increases sensitivity to cocaine through adulthood. Establishment of this method significantly expands the songbird drug exposure model, and holds promise for better appreciation of mechanisms important to sensorimotor learning that is dependent upon successful progress through sensitive periods of CNS development.
机译：斑马雀正在鸣禽在近似青春期的敏感发展期间学习声乐模式。将这些动物暴露在传感器的时期在传感器的激动蛋白激动剂中，改变成年期生产的歌曲模式。因此，鸣禽具有独特的价值，研究药物暴露对自然学习行为的发展效果。这种动物模型的缺失特征是研究毒品加强行为的方法。为了解决这个差距，我们有适应的地方调理方法，以前用于确定歌唱行为是有益的，研究可卡因加强行为。我们已经发现可卡因剂量依赖性地加强了与哺乳动物物种中观察到的效力的地方调节和厌恶。使用这种地方调理方法使我们能够确定在感官电流学习期间给药时，Delta-9-THC施用，但不是尼古丁通过成年期持续增加对可卡因的敏感性。该方法的建立显着扩展了鸣禽药物曝光模型，并持有希望更好地欣赏对传感器学习的重要机制，这些机制取决于通过CNS开发的敏感时期取得成功进展。

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