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5-HT2A receptors modulate dopamine D-2-mediated maternal effects

机译：5-HT2A受体调节多巴胺D-2介导的母体效应

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Serotonin 5-HT2A receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors. It is highly likely that 5-HT2A receptors may also modulate the D-2-mediated maternal effects. The present study investigated this issue and also explored the possible behavioral mechanisms. We tested the effects of two D-2 drugs (an agonist quinpirole: 0.5, 1.0 mg/kg, and a potent D-2 antagonist haloperidol: 0.05, 0.10 mg/kg, sc) and their combinations with two 5-HT2A drugs (a selective 5-HT2A agonist TCB-2: 2.5 mg/kg, and 5-HT2A antagonist MDL100907, 1.0 mg/kg, sc) on maternal behavior in Sprague-Dawley postpartum females. Individually, TCB-2 (2.5 mg/kg, sc) and quinpirole (0.5 and 1.0 mg/kg, sc) reduced pup preference and disrupted home-cage maternal behavior. In contrast, haloperidol (0.10 mg/kg, cc) only disrupted home-cage maternal behavior, but did not suppress pup preference. MDL100907 (1.0 mg/kg, sc) by itself had no effect on either pup preference or maternal behavior. When administered in combination, pretreatment of TCB-2 did not alter quinpirole's disruption of pup preference and home-cage maternal behavior (possibly due to the floor effect), however, it did enhance haloperidol's disruption of pup retrieval in the home cage. MDL100907 had no effect both quinpirole's and haloperidol's disruption of pup preference and home-cage maternal behavior. Interestingly, haloperidol attenuated TCB-2's disruptive effect on pup preference. These findings suggest that activation of 5-HT2A receptors tends to enhance D-2 -mediated maternal disruption, whereas blockade of 5-HT2A receptors is less effective. They also suggest that 5-HT2A receptors may have a direct effect on maternal behavior independent of their interaction with D-2 receptors. The possible behavioral and neural mechanisms by which 5HT(2A)- and D-2-mediated maternal effects and their interaction are discussed.
机译：在整个中索洛替蛋白和中皮质的多巴胺途径中表达血清素5-HT2A受体，并且该受体系统的操纵对多巴胺功能和多巴胺介导的行为具有深远的影响。 5-HT2A受体很可能还可以调节D-2介导的母体效果。本研究调查了这个问题，并探讨了可能的行为机制。我们测试了两种D-2药物的影响（激动剂喹喔：0.5,1.0mg / kg和有效的D-2拮抗剂氟哌啶醇：0.05,0.10mg / kg，sc）及其与两种5-ht2a药物的组合（一种选择性5-HT2A激动剂TCB-2：2.5mg / kg和5-HT2A拮抗剂MDL100907，Sprague-Dawley产后女性的母体行为上的母体行为。单独地，TCB-2（2.5mg / kg，sc）和喹喔（0.5和1.0 mg / kg，sc）减少了幼崽偏好并破坏了家庭笼子母体行为。相反，氟哌啶醇（0.10mg / kg，cc）只扰乱了家庭笼式母体行为，但没有抑制幼崽偏好。 MDL100907（1.0mg / kg，sc）本身对幼崽偏好或母体行为没有影响。当组合施用时，TCB-2的预处理没有改变奎尼醛的幼崽偏好和家庭笼子母体行为的破坏（可能是由于地板效应），然而，它确实增强了Haloperidol在家庭笼子里的幼崽检索的破坏。 MDL100907 Quinpirole和Haloperidol对幼崽偏好和家庭笼子母体行为的破坏没有影响。有趣的是，Haloperidol减弱了TCB-2对幼崽偏好的破坏性影响。这些发现表明，5-HT2A受体的激活倾向于提高D-2介导的母体破坏，而5-HT2A受体的阻断效果较小。他们还表明，5-HT2A受体可能直接影响母体行为，与其与D-2受体的相互作用无关。讨论了5HT（2A） - 和D-2介导的母体效应及其相互作用的可能行为和神经机制。

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