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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Morphine administered post-trial can induce potent conditioned morphine effects
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Morphine administered post-trial can induce potent conditioned morphine effects

机译：吗啡施用后试验可以诱导有效的调节吗啡效应

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Morphine has substantial pro-dopamine effects and in rodents, this is expressed in behavior as increased locomotor activation. Here we administered post-trial 3 dose levels of morphine (3.0, 5.0 and 10.0 mg/kg) or vehicle either immediately or after a 15 min delay to different groups of rats following a brief (5 min) exposure to a novel test environment. Three post-trial injections were administered on three successive days. One day after the first post-trial morphine injections, the non-drug activity levels in the immediate post-trial morphine treatment groups were selectively increased compared to vehicle groups. The activity effects were potentiated with repeated immediate post-trial morphine treatments but the same morphine treatments given after a 15 min post-trial delay did not increase activity in any tests and did not differ from vehicle. Subsequently, all groups were given 5 daily non-drug test sessions as an extinction protocol. The increased activity levels in the 5.0 and 10.0 mg/kg immediate post-trial morphine groups were sustained over the five extinction sessions. Two days later all groups were given a 30 min non-drug test and the 5.0 and 10.0 immediate post-trial groups continued to exhibit a heightened level of activity relative to vehicle restricted to the initial 10 min of the test session. There were no other group differences. The findings that the locomotor stimulant effects in the immediate post-test morphine groups occurred on non-drug tests and that the same morphine treatments given 15 min post-test were without effect are consistent with a conditioned morphine effect. In that acquisition of familiarization with a new environment is a basic learning process that engages consolidation mechanisms, it is possible that the immediate post-trial morphine effects that occur concurrently with consolidation can become incorporated into this consolidation process and subsequently be expressed as a conditioned drug effect.
机译：吗啡具有大量的促多巴胺效应和啮齿动物，这在行为中表达为流动热激活增加。在这里，我们在短暂（5分钟）暴露于新型测试环境后，立即或后，立即或后，立即或后，立即或后，立即或后，立即或后，立即或后，立即或之后延迟到不同的大鼠。连续三天进行三次试行后注射。在第一次试验后的吗啡注射后，有一天，与载体组相比，立即试验后的吗啡治疗组的非药物活性水平被选择性地增加。活性效应与反复试验后的吗啡治疗（相同的尿液后试验后延迟后给出的同样的吗啡治疗没有增加任何测试中的活性，并且与载体不同。随后，将所有群体均为5例每日非药物测试会作为灭绝方案。 5.0和10.0mg / kg即时试验后的吗啡组的增加的活性水平受到五次灭绝会话的持续性。两天后，所有群体都有30分钟的非药物测试，5.0和10.0立即试后群体继续表现出相对于车辆最初10分钟的车辆的高度活动水平。没有其他群体差异。在非药物测试中发生直接测试式吗啡组的运动兴奋剂效应的结果，并且给予15分钟后的相同的吗啡处理没有效果与条件的吗啡效应一致。在利用新环境熟悉的是涉及合并机制的基本学习过程中，可以将同时发生的正常试验吗啡效应与固结同时发生的作用可以纳入该固结过程中，随后表达为条件药物影响。

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