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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prenatal melamine exposure impairs cognitive flexibility and hippocampal synaptic plasticity in adolescent and adult female rats
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Prenatal melamine exposure impairs cognitive flexibility and hippocampal synaptic plasticity in adolescent and adult female rats

机译：产前三聚氰胺曝光损害青少年和成年女性大鼠的认知柔韧性和海马突触可塑性

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摘要

Prenatal melamine exposure (PME) affects spatial cognition in adolescent male rats and impairs synaptic functions. Strikingly, these effects can persist into adulthood. The current experiments examined whether PME-induced behavioral defects would be observed in female offspring, and how these effects varied with age (adolescent and adult). After female rats were exposed to melamine through their entire gestational period (GD), their spatial cognition was tested using water maze tasks at postnatal day 36 (PD36) and PD90. Long-term potentiation (LTP) and long-term depression (LTD) were recorded from the hippocampal Schaffer collaterals to the CAl area. Results indicated that PME led to substantial reversal learning deficits and disrupted LTD at both PD36 and PD90. Additionally, PME did not affect LTP, although a lower fEPSP slope was observed in the adolescent PME-treated group than in the adult PME-treated group. Additionally, PME did not induce a horizontal shift in the synaptic modification threshold but caused a downward shift of the frequency-response curve at the low-frequency stimulation (LFS) of 1.0 Hz. However, the paired-pulse facilitation (PPF) ratio and the input/output function were not affected. Although the expression of both NR1 and NR2B subunits of NMDA receptors were diminished at PD36, the NR1 level was not affected at PD90. These findings suggest that PME impairs spatial memory in adolescent and adult females, and the impairments of hippocampal synaptic function via the inhibition of NMDAR expression may play a role in these effects.
机译：产前三聚氰胺暴露（PME）影响青少年雄性大鼠的空间认知并损害突触功能。令人惊讶的是，这些效果可以坚持到成年期。目前的实验检测了是否在女性后代观察到PME引起的行为缺陷，以及这些效果如何随年龄（青少年和成人）而变化。通过整个妊娠期（GD）将雌性大鼠暴露于三聚氰胺后，使用产后第36天（PD36）和PD90的水迷宫任务来测试它们的空间认知。长期电压（LTP）和长期凹陷（LTD）从海马Schaffer侧面记录到Cal区域。结果表明，PD36和PD90的PME将导致大量逆转学习赤字和中断有限公司。另外，PME不影响LTP，尽管在青少年PME处理组中观察到低于成人PME处理基团的下部FEPSP斜率。另外，PME没有引起突触修改阈值的水平移位，但导致1.0Hz的低频刺激（LF）处的频率响应曲线的向下移位。但是，配对脉冲促进（PPF）比率和输入/输出功能不受影响。尽管在PD36下降低了NR1和NR2B亚基的NR1和NR2B亚基的表达，但NR1水平在PD90的影响下不受影响。这些发现表明，PME损害青少年和成年女性的空间记忆，并且通过抑制NMDAR表达的海马突触功能的损伤可能在这些效果中起作用。

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  • 作者

    An Lei; Li Jia; Luo Le; Huang Peidong; Liu Peidong; Tang Chunzhi; Sun Wei;

  • 作者单位

    Guangzhou Univ Chinese Med Med Coll Acupuncture Moxibust &

    Rehabil Guangzhou 510006 Peoples R;

    Guangzhou Univ Chinese Med Med Coll Acupuncture Moxibust &

    Rehabil Guangzhou 510006 Peoples R;

    Guiyang Univ Tradit Chinese Med Affiliated Hosp 1 Guiyang 550001 Peoples R China;

    Yunnan Univ TCM Med Coll Acupuncture Moxibust &

    Rehabil Kunming 650500 Yunnan Peoples R China;

    Guangzhou Univ Chinese Med Med Coll Acupuncture Moxibust &

    Rehabil Guangzhou 510006 Peoples R;

    Guangzhou Univ Chinese Med Med Coll Acupuncture Moxibust &

    Rehabil Guangzhou 510006 Peoples R;

    Guangzhou Univ Chinese Med Med Coll Acupuncture Moxibust &

    Rehabil Guangzhou 510006 Peoples R;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Age; Cognitive flexibility; Female rats; Melamine; Synaptic function;

    机译：年龄;认知灵活性;女性大鼠;三聚氰胺;突触功能;

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