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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of the prodrug Vyvanse on spatial working memory and adiposity in rats
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The effects of the prodrug Vyvanse on spatial working memory and adiposity in rats

机译：Prodrug Vyvanse对大鼠空间工作记忆和肥胖的影响

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摘要

The present study investigated the influence of Vyvanse (lisdexamfetamine), a psychomotor stimulant, on spatial working memory, body weight, and adiposity in rats. Control and experimental rats were placed in individual cages equipped with a running wheel, and food and water were provided ad-libitum. The study was divided into three periods: 1) habituation, 2) experimental, and 3) withdrawal. Control rats received a placebo in periods 1, 2 and 3, while experimental rats received a placebo in periods 1 and 3. Experimental rats received a treatment of Vyvanse in place of the placebo during period 2. Spatial working memory was examined by utilizing the methodology of the Morris Water Maze. Rats were evaluated by performance in the maze each day during the experimental and withdrawal periods. Each assessment consisted of two trials. The first was a sample trial in which an escape platform was discovered by trial and error. The second was a test trial in which the platform location was recalled using working memory. Platform placement and start location of the rats were changed every session. It was hypothesized that Vyvanse would effectively enhance spatial working memory, and significantly decrease body weight and adiposity without side effects on activity level and anxiety in rats. Results supported the hypothesis. Compared to control rats, Vyvanse treated rats had significant improvement in working memory and significantly lowered body weight, as well as significantly decreased mesenteric, renal, and epididymal adiposity. No significant effects on activity level and task specific anxiety were noted in experimental animals. When compared to placebo treatment, Vyvanse treatment produced no significant influence on food and water intake. It was concluded that Vyvanse treatment in rats can enhance spatial working memory, and decrease adiposity without suppressing normal appetite.
机译：本研究调查了vyvanse（锂蛋白氟胺），精神刺激剂对大鼠空间工作记忆，体重和肥胖的影响。将控制和实验大鼠置于配备有运行轮的单个笼子中，并且提供了ad-libitum的食物和水。该研究分为三个时期：1）习惯，2）实验，3）撤回。对照大鼠在1,2和3时接收安慰剂，而实验大鼠在1和3期间接受安慰剂。实验大鼠在期间接受了vyvanse的治疗。通过利用方法来检查空间工作记忆莫里斯水迷宫。在实验和戒断期间每天在迷宫中的性能评估大鼠。每次评估都包括两项试验。第一个是一种采样试验，其中通过试验和错误发现了逃生平台。第二个是使用工作存储器回忆平台位置的测试试验。每个会话都更改了大鼠的平台放置和起始位置。假设Vyvanse将有效增强空间工作记忆，并显着降低对大鼠活性水平和焦虑的副作用而显着降低体重和肥胖。结果支持假设。与对照大鼠相比，vyvanse治疗的大鼠在工作记忆中具有显着改善，体重显着降低，以及显着降低的肠系膜，肾和附睾肥胖。在实验动物中注意到对活动水平和任务特异性焦虑没有显着影响。与安慰剂治疗相比，Vyvanse治疗对食物和水的摄入没有显着影响。结论是，大鼠的vyvanse治疗可以增强空间工作记忆，并降低肥胖而不抑制正常食欲。

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