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The role of metabotropic glutamate receptors in addiction: Evidence from preclinical models

机译：代谢谷氨酸受体在成瘾中的作用：来自临床前模型的证据

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摘要

Addiction is a chronic disorder characterised by repeated bouts of drug taking, abstinence and relapse. The addicted state may be in part due to drug-induced neuroadaptations in the mesocorticolimbic and corticostriatal pathways. Recently focus has been on the role of aberrant glutamate transmission and its contribution to the hierarchical control over these systems. This review will expand our current knowledge of the most recent advances that have been made in preclinical animal models that provide evidence that implicate metabotropic glutamate receptors (mGluRs) in contributing to the neuroadaptations pertinent to addiction, as well as the role of Homer proteins in regulating these responses. The recent discovery of receptor mosaics will be discussed which add an additional dimension to the complexity of understanding the mechanism of glutamate mediated behaviours. Finally this review introduces a new area related to glutamatergic responses, namely microRNAs, that may become pivotal in directing our future understanding of how to best target intervention strategies to prevent addictive behaviours.
机译：成瘾是一种慢性疾病，其特征在于重复的药物服用，禁欲和复发。上瘾的状态可能部分是由于中皮质罗蓟匠和皮质棘病毒途径中的药物诱导的神经展开。最近重点一直是异常谷氨酸传输的作用及其对对这些系统的分层控制的贡献。本综述将扩大我们目前在临床前动物模型中所做的最新进展的最新进展，提供致力于致癌代谢谷氨酸受体（MGLURURS）在贡献与成瘾相关的神经途径，以及HOMER蛋白在调节中的作用这些反应。最近的发现将讨论受体马赛克的发现，这增加了对理解谷氨酸介导行为的机制的复杂性的额外尺寸。最后，介绍了与谷胱甘粕反应有关的新区域，即MicroRNA，这可能会导致我们未来的理解如何最佳的目标干预策略，以防止上瘾的行为。

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