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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of ketamine on exploratory behaviour in BALB/C and C57BL/6 mice
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Effect of ketamine on exploratory behaviour in BALB/C and C57BL/6 mice

机译：氯胺酮对BALB / C和C57BL / 6小鼠探索性行为的影响

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In this study, we evaluated the effect of ketamine on exploratory locomotion behaviours in the Balb/c and C57BL/6 strains of mice, which differ in their locomotion behaviours. Intraperitoneal administration of ketamine at three different doses (1, 5 or 10 mg/kg, 0.1 ml/10 gr body weight) was performed on adult male Balb/c and C57BL/6 mice. The same volume of saline was applied to the control group. The open-field and elevated plus maze apparatus were used to evaluate exploratory locomotion. In the open-field test, Balb/c mice less spend time in the centre of the field and was decreased locomotor activity compared to C57BL/6 mice (p < 0.01). Ketamine treatment of Balb/c mice at 10 mg/kg dose caused an increase in locomotor activity and an increase in the amount of time spent in the centre in the open-field test, compared to the control group (p < 0.05). In C57BL/6 mice, ketamine treatment (1 and 10 mg/kg) decreased locomotor activity (p < 0.05). In C57BL/6 mice, the three different doses of ketamine application each caused a decrease in the frequency of centre crossing (p < 0.001) and the spent time in the centre (p < 0.05). In the elevated plus maze, the number of open-arm entries, the percentage of open-arm time and total arm entries were decreased in Balb/c mice compared to C57BL/6 mice (p < 0.001). Ketamine treatment of Balb/c mice at 10 mg/kg dose caused an increase in the open-arm activity (p < 0.001). Ketamine application (10 mg/kg) decreased the open-arm activity in C57BL/6 mice (p < 0.05). A subanaesthetic dose of ketamine increased exploratory locomotion in Balb/c mice. In contrast, a subanaesthetic dose of ketamine decreased exploratory locomotion in C57BL/6 mice. In conclusion, hereditary factors may play an important role in ketamine-induced responses.
机译：在这项研究中，我们评估了氯胺酮对BALB / C和C57BL / 6株小鼠的探索性运动行为的影响，其在其运动行为中不同。在成年雄性BALB / C和C57BL / 6小鼠上进行腹腔内施用三种不同剂量（1,5或10mg / kg，0.1mL / 10gr体重）。将相同体积的盐水施用于对照组。开放式和升高的加迷宫设备用于评估探索运动。在开场测试中，与C57BL / 6小鼠相比，BALB / C小鼠少花费时间，并减少运动活性减少（P <0.01）。与对照组相比，氯胺酮在10mg / kg剂量下的氯胺酮治疗Balb / c小鼠的促进剂量增加，并且在开放式测试中所花费的时间的增加量（P <0.05）。在C57BL / 6小鼠中，氯胺酮处理（1和10mg / kg）降低了运动活性（P <0.05）。在C57BL / 6小鼠中，三种不同剂量的氯胺酮应用各自导致中心交叉频率（P <0.001）和中心的花费时间（P <0.05）。在升高的加迷宫中，与C57BL / 6小鼠相比，张开臂条目的数量，开臂时间和总臂总条目的百分比减少（P <0.001）。氯胺酮治疗Balb / C小鼠的10mg / kg剂量导致开臂活动的增加（P <0.001）。氯胺酮施用（10mg / kg）在C57BL / 6小鼠中降低了开臂活动（P <0.05）。氯胺酮的子瘤剂量增加Balb / C小鼠的探索性运动。相比之下，氯胺酮的子饱和剂量减少了C57BL / 6小鼠的探索性运动。总之，遗传因素可能在氯胺酮诱导的反应中发挥重要作用。

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