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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of ketamine on exploratory behaviour in BALB/C and C57BL/6 mice
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Effect of ketamine on exploratory behaviour in BALB/C and C57BL/6 mice

机译：氯胺酮对BALB / C和C57BL / 6小鼠探索行为的影响

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In this study, we evaluated the effect of ketamine on exploratory locomotion behaviours in the Balb/c and C57BL/6 strains of mice, which differ in their locomotion behaviours. Intraperitoneal administration of ketamine at three different doses (1, 5 or 10 mg/kg, 0.1 ml/10 gr body weight) was performed on adult male Balb/c and C57BL/6 mice. The same volume of saline was applied to the control group. The open-field and elevated plus maze apparatus were used to evaluate exploratory locomotion. In the open-field test, Balb/c mice less spend time in the centre of the field and was decreased locomotor activity compared to C57BL/6 mice (p < 0.01). Ketamine treatment of Balb/c mice at 10 mg/kg dose caused an increase in locomotor activity and an increase in the amount of time spent in the centre in the open-field test, compared to the control group (p < 0.05). In C57BL/6 mice, ketamine treatment (1 and 10 mg/kg) decreased locomotor activity (p < 0.05). In C57BL/6 mice, the three different doses of ketamine application each caused a decrease in the frequency of centre crossing (p < 0.001) and the spent time in the centre (p < 0.05). In the elevated plus maze, the number of open-arm entries, the percentage of open-arm time and total arm entries were decreased in Balb/c mice compared to C57BL/6 mice (p < 0.001). Ketamine treatment of Balb/c mice at 10 mg/kg dose caused an increase in the open-arm activity (p < 0.001). Ketamine application (10 mg/kg) decreased the open-arm activity in C57BL/6 mice (p < 0.05). A subanaesthetic dose of ketamine increased exploratory locomotion in Balb/c mice. In contrast, a subanaesthetic dose of ketamine decreased exploratory locomotion in C57BL/6 mice. In conclusion, hereditary factors may play an important role in ketamine-induced responses.
机译：在这项研究中，我们评估了氯胺酮对Balb / c和C57BL / 6品系小鼠探索性运动行为的影响，这两种小鼠的运动行为不同。对成年雄性Balb / c和C57BL / 6小鼠进行三种不同剂量（1、5或10 mg / kg，0.1 ml / 10 gr体重）的氯胺酮腹膜内给药。将相同体积的盐水应用于对照组。使用旷场和高架迷宫装置评估探索性运动。在野外试验中，与C57BL / 6小鼠相比，Balb / c小鼠在野外中心的时间更少，运动能力降低（p <0.01）。与对照组相比，氯胺酮以10 mg / kg剂量的Balb / c小鼠进行的氯胺酮治疗导致运动活性增加，并且在开放视野试验中增加了在中心进行试验的时间（p <0.05）。在C57BL / 6小鼠中，氯胺酮治疗（1和10 mg / kg）降低了运动活性（p <0.05）。在C57BL / 6小鼠中，三种不同剂量的氯胺酮的使用各自导致中心交叉频率（p <0.001）和中心时间的减少（p <0.05）。与C57BL / 6小鼠相比，在高架迷宫中，Balb / c小鼠的张开双臂的次数，张开双臂的时间百分比和总手臂进入的次数减少了（p <0.001）。氯胺酮以10 mg / kg的剂量对Balb / c小鼠进行的氯胺酮处理导致开臂活性增加（p <0.001）。氯胺酮的应用（10 mg / kg）降低了C57BL / 6小鼠的张开臂活动（p <0.05）。亚麻醉剂量的氯胺酮可增加Balb / c小鼠的探索运动。相反，亚麻醉剂量的氯胺酮可降低C57BL / 6小鼠的探索运动。总之，遗传因素可能在氯胺酮引起的反应中起重要作用。

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