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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Diminished conditioned responding to the nicotine stimulus by antidepressant drugs with differing specificity for the serotonin and norepinephrine transporter
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Diminished conditioned responding to the nicotine stimulus by antidepressant drugs with differing specificity for the serotonin and norepinephrine transporter

机译：通过抗抑郁药物对尼古丁药物进行抗抑郁药物的抗抑郁药物的抗抑郁药物，具有不同特异性的调理结果减少

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People diagnosed with depression also tend to have a co-morbid nicotine addiction. Thus, there is interest in whether medications used to treat depression alter the effects of nicotine. This study assessed whether the antidepressant drugs citalopram, imipramine, and reboxetine, with differing specificity for the serotonin and norepinephrine transporter, altered responding controlled by the conditional stimulus (CS) effects of nicotine. Rats received intermixed 20-min nicotine (0.4 mg base/kg, SC) and saline sessions. On nicotine sessions, rats had intermittent access to sucrose; no sucrose was available on saline sessions. After discrimination performance stabilized and a nicotine generalization curve (0.025-0.4 mg/kg) was established, the antidepressant drugs were assessed. In these tests, rats were pretreated with citalopram (1-17 mg/kg), imipramine (1-17 mg/kg), or reboxetine (1-30 mg/kg) before the training dose of nicotine and placement in a chamber for a 4-min extinction test. At the higher doses, all three antidepressant drugs blocked responding evoked by the nicotine CS and decreased nicotine-induced hyperactivity. When these higher doses of citalopram, imipramine, and reboxetine were tested alone (no nicotine), they decreased chamber activity and/or dipper entries. Nevertheless, all three drugs produced partial or complete blockade of the CS effects of nicotine at doses that produced no effect on dipper entries or chamber entries. This finding suggests that both neurotransmitters play a role in the CS effects of nicotine and that modifications in these systems by antidepressants may be clinically relevant.
机译：被诊断患有抑郁症的人也往往具有顽固的尼古丁成瘾。因此，有兴趣的是用于治疗抑郁症的药物是否改变了尼古丁的影响。该研究评估了抗抑郁药物西酞普兰，脂染氨酸和再禁止的血清素和去甲肾上腺素转运蛋白的特异性，改变了由尼古丁的条件刺激（CS）对照控制的响应。接受混合20分钟尼古丁（0.4mg碱/ kg，sc）和盐水会话的大鼠。在尼古丁会议上，大鼠对蔗糖的间歇性进入;盐水会话中没有蔗糖。在确定鉴别性能和尼古丁泛化曲线（0.025-0.4mg / kg）后，评估抗抑郁药物。在这些测试中，在尼古丁的训练剂量和放置在腔室中之前，用西普兰（1-17mg / kg），脂甲脒（1-17mg / kg），脂甲氨酰胺（1-17mg / kg），脂盐（1-10mg / kg）或雷嵌丁胺（1-30mg / kg）进行预处理大鼠4分钟的消失测试。在较高剂量的剂量，所有三种抗抑郁药物被尼古丁Cs诱发的响应诱导并降低了尼古丁诱导的多动。当单独测试这些较高剂量的西酞普兰，脂甲脒和再抑制液（没有尼古丁），它们减少了室活性和/或浸渍条目。尽管如此，所有三种药物都会产生尼古丁对尼古丁的CS效应的部分或完全阻断，这些含量对浸染剂条目或分钟条目没有影响。该发现表明，神经递质均在尼古丁的CS效应中发挥作用，并且通过抗抑郁剂在这些系统中的修饰可能是临床相关的。

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