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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Diminished conditioned responding to the nicotine stimulus by antidepressant drugs with differing specificity for the serotonin and norepinephrine transporter
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Diminished conditioned responding to the nicotine stimulus by antidepressant drugs with differing specificity for the serotonin and norepinephrine transporter

机译：对5-羟色胺和去甲肾上腺素转运蛋白具有不同特异性的抗抑郁药对尼古丁刺激的反应性减弱

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People diagnosed with depression also tend to have a co-morbid nicotine addiction. Thus, there is interest in whether medications used to treat depression alter the effects of nicotine. This study assessed whether the antidepressant drugs citalopram, imipramine, and reboxetine, with differing specificity for the serotonin and norepinephrine transporter, altered responding controlled by the conditional stimulus (CS) effects of nicotine. Rats received intermixed 20-min nicotine (0.4 mg base/kg, SC) and saline sessions. On nicotine sessions, rats had intermittent access to sucrose; no sucrose was available on saline sessions. After discrimination performance stabilized and a nicotine generalization curve (0.025-0.4 mg/kg) was established, the antidepressant drugs were assessed. In these tests, rats were pretreated with citalopram (1-17 mg/kg), imipramine (1-17 mg/kg), or reboxetine (1-30 mg/kg) before the training dose of nicotine and placement in a chamber for a 4-min extinction test. At the higher doses, all three antidepressant drugs blocked responding evoked by the nicotine CS and decreased nicotine-induced hyperactivity. When these higher doses of citalopram, imipramine, and reboxetine were tested alone (no nicotine), they decreased chamber activity and/or dipper entries. Nevertheless, all three drugs produced partial or complete blockade of the CS effects of nicotine at doses that produced no effect on dipper entries or chamber entries. This finding suggests that both neurotransmitters play a role in the CS effects of nicotine and that modifications in these systems by antidepressants may be clinically relevant.
机译：被诊断出患有抑郁症的人也倾向于患有并存的尼古丁成瘾。因此，人们感兴趣的是用于治疗抑郁症的药物是否会改变尼古丁的作用。这项研究评估了抗抑郁药西酞普兰，丙咪嗪和瑞波西汀是否对5-羟色胺和去甲肾上腺素转运蛋白具有不同的特异性，并通过尼古丁的条件刺激（CS）作用改变了应答。大鼠接受混合20分钟尼古丁（0.4 mg碱/ kg，SC）和生理盐水的混合。在尼古丁疗程中，大鼠断断续续地获取蔗糖。在生理盐水疗程中没有蔗糖。在鉴别性能稳定并建立了尼古丁泛化曲线（0.025-0.4 mg / kg）后，评估了抗抑郁药。在这些测试中，在对尼古丁进行训练剂量并将其放置在试验室中之前，先用西酞普兰（1-17 mg / kg），丙咪嗪（1-17 mg / kg）或瑞波西汀（1-30 mg / kg）对大鼠进行预处理。 4分钟消光测试。在较高剂量下，所有三种抗抑郁药均会阻断尼古丁CS引起的反应并降低尼古丁引起的机能亢进。当单独测试这些较高剂量的西酞普兰，丙咪嗪和瑞波西汀（不含尼古丁）时，它们会降低房室活动和/或浸入物。然而，在不影响北斗七星进入或分室进入的剂量下，所有三种药物均会部分或完全阻断尼古丁的CS效应。这一发现表明，两种神经递质都在尼古丁的CS效应中起作用，并且抗抑郁药对这些系统的修饰可能与临床有关。

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