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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: Increased startle reactivity and perseverative behavior
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Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: Increased startle reactivity and perseverative behavior

机译：表征神经剂诱导的大鼠癫痫发作活性的行为效应：增加了惊吓反应性和持续性行为

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The development and deployment of next-generation therapeutics to protect military and civilian personnel against chemical warfare nerve agent threats require the establishment and validation of animal models. The purpose of the present investigation was to characterize the behavioral consequences of soman (GD)-induced seizure activity using a series of behavioral assessments. Male Sprague-Dawley rats (n = 24), implanted with a transmitter for telemetric recording of encephalographic signals, were administered either saline or 1.0 LD 50 GD (110 μg/kg, sc) followed by treatment with a combination of atropine sulfate (2 mg/kg, im) and the oxime HI-6 (93.6 mg/kg, im) at 1 min post-exposure. Seizure activity was allowed to continue for 30 min before administration of the anticonvulsant diazepam (10 mg/kg, sc). The animals that received GD and experienced seizure activity had elevated startle responses to both 100- and 120-dB startle stimuli compared to control animals. The GD-exposed animals that had seizure activity also exhibited diminished prepulse inhibition in response to 120-dB startle stimuli, indicating altered sensorimotor gating. The animals were subsequently evaluated for the acquisition of lever pressing using an autoshaping procedure. Animals that experienced seizure activity engaged in more goal-directed (i.e., head entries into the food trough) behavior than did control animals. There were, however, no differences between groups in the number of lever presses made during 15 sessions of autoshaping. Finally, the animals were evaluated for the development of fixed-ratio (FR) schedule performance. Animals that experienced GD-induced seizure activity engaged in perseverative food trough-directed behaviors. There were few differences between groups on other measures of FR schedule-controlled behavior. It is concluded that the GD-induced seizure activity increased startle reactivity and engendered perseverative responding and that these measures are useful for assessing the long-term effects of GD exposure in rats.
机译：下一代治疗方法的开发和部署保护军事和民用人员免受化学战神经代理威胁需要建立和验证动物模型。本研究的目的是使用一系列行为评估表征Soman（GD）的行为后果，诱导癫痫发作活动。植入发射器的雄性Sprague-Dawley大鼠（n = 24）用于抵抗脑接近信号，施用盐水或1.0LD 50 gd（110μg/ kg，sc），然后用阿托甘啡硫酸盐的组合治疗（2 mg / kg，im）和肟Hi-6（93.6mg / kg，IM）在1分钟后暴露。在施用抗惊厥二Zezam（10mg / kg，sc）之前，允许癫痫发作活性在施用抗惊厥药物（10mg / kg）之前继续。与对照动物相比，接受Gd和经验癫痫发作活性的动物对100-和120dB的震动刺激升高了惊吓响应。具有癫痫发作活性的GD暴露的动物还表现出响应于120dB的震动刺激而降低的预浸性抑制，表明感觉电机改变。随后评估动物的使用自动扫描程序采集杠杆按压。经历癫痫发作活动的动物从事更多目标导向（即，头部条目进入食物槽）的行为而不是对照动物。然而，在15个自动扫描期间，杠杆压力机的数量之间没有差异。最后，评估了动物的固定比率（FR）时间表的发展。经历过GD诱导的癫痫发作活动的动物从事坚持不懈的食物槽的行为。关于FR日程控制行为的其他措施之间的群体之间几乎没有差异。得出结论，GD诱导的癫痫发作活性增加了惊吓反应性和有利于持续反应，并且这些措施可用于评估GD暴露在大鼠中的长期影响。

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