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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Running wheel activity protects against increased seizure susceptibility in ethanol withdrawn male rats
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Running wheel activity protects against increased seizure susceptibility in ethanol withdrawn male rats

机译：运行的车轮活性可以防止乙醇撤出雄性大鼠的癫痫发作易感性增加

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Ethanol withdrawal is a dysphoric condition that arises from termination of ethanol intake by dependent individuals. Common withdrawal symptoms include anxiety, increased reactivity to stimuli and increased seizure susceptibility as well as the risk of increased seizure severity. We use an animal model of dependence and withdrawal to study withdrawal behaviors and potential underlying neurobiological mechanisms. For a number of years, we have quantified pentylenetetrazol seizure thresholds as an assessment of ethanol withdrawal at both one day and three days of withdrawal. Typically, we see a significant decrease in seizure threshold (increased sensitivity to seizure induction) that persists through three days of withdrawal for male rats. Increasing evidence indicates that voluntary exercise affords protection against various challenges to physical and psychological health, including ethanol-related challenges. Therefore, the current study investigated the effect of voluntary wheel running on seizure susceptibility following chronic ethanol administration and withdrawal. We found that voluntary wheel running attenuated the increased sensitivity to pentylenetetrazol-induced seizures observed with ethanol withdrawal, at both the one-day and three-day time points. This result was especially interesting as animals with access to the running wheels consumed more of the ethanol-containing diet. These findings showed that chronic voluntary wheel running reduces the severity of ethanol withdrawal in our animal model and suggest that exercise-based interventions may have some utility in the clinical management of heavy drinking and alcohol withdrawal.
机译：乙醇戒断是一种疑惑条件，依赖于受抚养人的乙醇摄入量。常见的戒断症状包括焦虑，增加对刺激的反应性，并增加癫痫发作易感性以及增加癫痫发作严重程度的风险。我们使用依赖性和戒断的动物模型来研究戒断行为和潜在的神经生物学机制。多年来，我们已经量化了五苯甲酸四唑癫痫阈值，作为一天乙醇戒断的评估和三天的戒断。通常，我们看到癫痫发作阈值的显着降低（增加对癫痫发育诱导的敏感性），其持续到雄性大鼠的三天缺失。越来越多的证据表明，自愿锻炼提供了对身体和心理健康的各种挑战的保护，包括与乙醇有关的挑战。因此，目前的研究调查了慢性乙醇给药后慢性乙醇给药和戒断后志愿车轮对癫痫发作敏感性的影响。我们发现，在一天和三天的时间点，志愿车轮衰减对乙醇戒断观察到的戊烯类四唑诱导的癫痫发作的敏感性增加。这种结果特别有趣，因为可以使用运行轮的动物消耗更多的含乙醇饮食。这些研究结果表明，慢性自愿车轮在动物模型中降低了乙醇戒断的严重程度，并表明基于运动的干预措施可能在临床管理中具有一些效用，饮酒和酒精戒断。

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