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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Anorexic effects of intra-VTA leptin are similar in low-fat and high-fat-fed rats but attenuated in a subgroup of high-fat-fed obese rats
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Anorexic effects of intra-VTA leptin are similar in low-fat and high-fat-fed rats but attenuated in a subgroup of high-fat-fed obese rats

机译：VTA内瘦蛋白的厌恶作用在低脂肪和高脂肪喂养的大鼠中具有相似，但在高脂肪喂养肥胖大鼠的亚组中衰减

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摘要

Leptin is an adiposity hormone that plays an important role in regulating food intake and energy homeostasis. This study investigated the effects of a high-fat (HF) and a low-fat, high-carbohydrate/sugar (LF) diet on leptin sensitivity in the ventral tegmental area (VTA) in rats. The animals were exposed to a HF or LF diet for 16 weeks. Then the effects of intra-VTA leptin (150 and 500 ng/side, unilateral dose) on food intake and body weights were investigated while the animals were maintained on the HF or LF diet. Long-term exposure to the HF or LF diet led to similar body weight gain in these groups. The HF-fed animals consumed a smaller amount of food by weight than the LF-fed animals but both groups consumed the same amount of calories. The bilateral administration of leptin into the VTA decreased food intake (72 h) and body weights (48 h) to a similar degree in the HF and LF-fed animals. When the HF-fed animals were ranked by body weight gain it was shown that the diet-induced obese rats (HF-fed DIO, upper quartile for weight gain) were less sensitive to the effects of leptin on food intake and body weights than the diet-resistant rats (HF-fed DR, lower quartile for weight gain). A control experiment with fluorescent Cy3-labeled leptin showed that leptin did not spread beyond the borders of the VTA. This study indicates that leptin sensitivity in the VTA is the same in animals that are exposed to a HF or LF diet. However, HF-fed DIO rats are less sensitive to the effects of leptin in the VTA than HF-fed DR rats. Leptin resistance in the VTA might contribute to overeating and weight gain when exposed to a HF diet. ? 2012 Elsevier Inc. All rights reserved.
机译：瘦素是一种肥胖的激素，在调节食物摄入和能量稳态中起着重要作用。本研究研究了高脂肪（HF）和低脂肪，高碳水化合物/糖（LF）饮食对大鼠腹侧引物区域（VTA）中的瘦素敏感性的影响。将动物暴露于HF或LF饮食16周。然后研究了VTA瘦蛋白（150和500ng /侧，单侧剂量）对食物摄入和体重的影响，同时将动物保持在HF或LF饮食上。长期暴露于HF或LF饮食导致这些组中的体重增加相似。 HF喂养的动物通过LF喂养动物消耗较少量的食物，但两组消耗相同量的卡路里。将瘦素施用到VTA中，将食物摄入（72小时）和体重（48小时）降低到HF和LF喂养动物中的相似程度。当HF喂养的动物被体重增加排名时，表明饮食诱导的肥胖大鼠（HF喂dDIO，体重增加的上四分位数）对瘦素对食物摄入和体重的影响敏感耐食性大鼠（HF喂养DR，重量增长低四分位数）。具有荧光Cy3标记的瘦蛋白的对照实验表明，瘦素没有超过VTA的边界。该研究表明，VTA中的瘦素敏感性在暴露于HF或LF饮食的动物中是相同的。然而，HF喂养的DIO大鼠对瘦素在VTA中的影响敏感而不是HF喂养博士大鼠。当暴露于HF饮食时，VTA中的瘦素抗性可能有助于暴饮暴食和体重增加。还2012年elsevier Inc.保留所有权利。

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