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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys.
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Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys.

机译：苯并二氮杂毒药型药物的认知损害作用：Gabaa受体亚型在恒河猴执行职能任务中的作用。

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摘要

The present studies evaluated the role of α1 and α5 subunit-containing GABAA receptors (α1GABAA and α5GABAA receptors, respectively) in the ability of benzodiazepine (BZ)-type drugs to alter performance in the cognitive domain of executive function. Five adult female rhesus monkeys (ages of 9-17years old) were trained on the object retrieval with detours (ORD) task of executive function. For the ORD task, the monkeys were required to retrieve food items from a clear box with one open end that was rotated to different positions along with varying placements of food. When the non-selective BZ triazolam and the α1GABAA-preferring agonists zolpidem and zaleplon were evaluated in the ORD task, deficits in performance occurred at doses that did not increase the latency of monkeys to initiate responding and/or increase the percentage of reaches that were incorrect (i.e., reaches in which food was not obtained). Cognition-impairing effects of triazolam and zolpidem in ORD were blocked by the α1GABAA-preferring antagonist, βCCT, whereas the α5GABAA-preferring antagonist XLi-093 blocked the effects of triazolam but not zolpidem. While these findings suggest a role for both α1GABAA and α5GABAA receptor mechanisms, α1GABAA receptor mechanisms appear to be sufficient for impairments in executive function induced by BZ-type drugs.
机译：本研究评估了含α1和α5亚单位的GABAA受体（α1Gabaa和α5gabaa受体，分别）在苯二氮卓（BZ）型药物的能力改变执行功能的认知领域的能力中的作用。五个成年女性恒河猴（旧的年龄为9-17岁）训练在执行职能的绕行（ORD）任务的对象检索。对于ORD任务，猴子被要求从一个透明盒子中检索食物物品，其中一个开口端旋转到不同的位置以及不同的食物的放置。当在ORD任务中评估非选择性BZ三唑仑和α1Gabaa偏好激动剂Zolpidem和Zaleplon时，性能缺陷发生在不增加猴子的潜伏期以启动响应和/或增加达到的达到的百分比不正确（即未获得食物的到达）。 Triazolam和Zolpidem以ord的认知损害效应被α1Gabaa-偏爱拮抗剂，βCCT阻断，而α5Gabaa-偏爱拮抗剂XLI-093阻断了三唑仑但不是Zolpidem的影响。虽然这些发现表明α1GaBAA和α5GaBAA受体机制的作用，但α1GaBAA受体机制似乎足以用于BZ型药物诱导的执行功能的损伤。

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